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Physicochemical properties and cell viability of shrimp chitosan films as affected by film casting solvents. I-potential use as wound dressing

2020Journal article Open access
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dc.contributor.authorEulálio, Hugo Yves C.
dc.contributor.authorVieira, Mariana
dc.contributor.authorFideles, Thiago B.
dc.contributor.authorTomás, Helena
dc.contributor.authorSilva, Suédina M. L.
dc.contributor.authorPeniche, Carlos A.
dc.contributor.authorFook, Marcus Vinícius L.
dc.date.accessioned2022-06-14T10:46:22Z
dc.date.available2022-06-14T10:46:22Z
dc.date.issued2020
dc.description.abstract: Chitosan solubility in aqueous organic acids has been widely investigated. However, most of the previous works have been done with plasticized chitosan films and using acetic acid as the film casting solvent. In addition, the properties of these films varied among studies, since they are influenced by different factors such as the chitin source used to produce chitosan, the processing variables involved in the conversion of chitin into chitosan, chitosan properties, types of acids used to dissolve chitosan, types and amounts of plasticizers and the film preparation method. Therefore, this work aimed to prepare chitosan films by the solvent casting method, using chitosan derived from Litopenaeus vannamei shrimp shell waste, and five different organic acids (acetic, lactic, maleic, tartaric, and citric acids) without plasticizer, in order to evaluate the effect of organic acid type and chitosan source on physicochemical properties, degradation and cytotoxicity of these chitosan films. The goal was to select the best suited casting solvent to develop wound dressing from shrimp chitosan films. Shrimp chitosan films were analyzed in terms of their qualitative assessment, thickness, water vapor permeability (WVP), water vapor transmission rate (WVTR), wettability, tensile properties, degradation in phosphate buffered saline (PBS) and cytotoxicity towards human fibroblasts using the resazurin reduction method. Regardless of the acid type employed in film preparation, all films were transparent and slightly yellowish, presented homogeneous surfaces, and the thickness was compatible with the epidermis thickness. However, only the ones prepared with maleic acid presented adequate characteristics of WVP, WVTR, wettability, degradability, cytotoxicity and good tensile properties for future application as a wound dressing material. The findings of this study contributed not only to select the best suited casting solvent to develop chitosan films for wound dressing but also to normalize a solubilization protocol for chitosan, derived from Litopenaeus vannamei shrimp shell waste, which can be used in the pharmaceutical industry.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEulálio, H. Y. C., Vieira, M., Fideles, T. B., Tomás, H., Silva, S. M., Peniche, C. A., & Fook, M. V. L. (2020). Physicochemical properties and cell viability of shrimp chitosan films as affected by film casting solvents. I-Potential use as wound dressing. Materials, 13(21), 5005. https://doi.org/10.3390/ma13215005pt_PT
dc.identifier.doi10.3390/ma13215005pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4327
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChitosanpt_PT
dc.subjectFilmpt_PT
dc.subjectSolubilitypt_PT
dc.subjectOrganic acidspt_PT
dc.subjectSolvent castingpt_PT
dc.subjectWound dressingpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titlePhysicochemical properties and cell viability of shrimp chitosan films as affected by film casting solvents. I-potential use as wound dressingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.issue21pt_PT
oaire.citation.startPage5005pt_PT
oaire.citation.titleMaterialspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCatanho da Silva Vieira
person.familyNameTomás
person.givenNameMariana
person.givenNameHelena
person.identifier556975
person.identifier.ciencia-idA915-E451-9EE1
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0001-5928-4237
person.identifier.orcid0000-0002-7856-2041
person.identifier.ridE-5991-2010
person.identifier.scopus-author-id6508104177
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication3a747114-6ab9-454b-985b-00cbf792e273
relation.isAuthorOfPublication.latestForDiscoverya98e3568-7a2a-4b9e-b13b-b570bf64d472
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