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Characterization of phenolic compounds and antioxidant activity of ethanolic extracts from flowers of Andryala glandulosa ssp. varia (Lowe ex DC.) R.Fern., an endemic species of Macaronesia region

2013Journal article Open access
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dc.contributor.authorGouveia, Sandra
dc.contributor.authorGonçalves, João
dc.contributor.authorCastilho, Paula C.
dc.date.accessioned2021-03-30T14:39:25Z
dc.date.available2021-03-30T14:39:25Z
dc.date.issued2013
dc.description.abstractAndryala glandulosa spp. varia (Lowe ex DC.) R.Fern. (Asteraceae), is a small shrub that grows in moun tains of Madeira Island, Fuerteventura and Lanzarote from Canary Islands. The flowerheads are used traditionally for the treatment of edemas and in homemade dermo-cosmetic preparations. In this paper the chemical composition of the extracts of this plant, used in folk medicine, and their antioxidant capacity were established; the presence of potentially harmful lactones, so commonly associated with related species used for the same purposes was also evaluated. A reversed-phase high performance liquid chromatography method (RP-HPLC) coupled with diode-array detection (DAD) and electrospray ionization mass spectrometry (ESI/MSn) was used for the characterization of phenolic com pounds in ethanol extracts of flowers from A. glandulosa spp. varia collected in Madeira Island. Total phenolic content (TPC) and total flavonoid content (TFC) were established and three assays (DPPH, ABTS and FRAP) were used to measure the antioxidant capacity of the dichloromethane and ethanol extracts. The dichloromethane extract of A. glandulosa contain long linear chain hydrocarbons and esters. In the alcoholic extracts, a total of 16 compounds were characterized based on their UV, mass spectra and HPLC retention time. Quinic acid and luteolin derivatives were found to be the main compounds. Quantification of caffeoylquinic acids (CQA) detected was performed by HPLC-DAD and 5-O-CQA and 3,5-O-diCQA were the major compounds (with values of 22.40 ± 0.21 and 59.69 ± 1.07 mg/100 g dried plant, respectively). Only the ethanol extract was active, revealing a high radical scavenging capacity and a moderate reducing potential. The potent antioxidant alcoholic extracts are composed mainly of hydroxycinnamic acid derivatives and flavonoids. The presence of sesquiterpene lactones was not detected. Since lactones are very common among related plants, like arnicas, and known to cause dermatitis and other unwanted effects, this can be an explanation for the preference for Andryala over other more easily available alternativespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGouveia, S., Gonçalves, J., & Castilho, P. C. (2013). Characterization of phenolic compounds and antioxidant activity of ethanolic extracts from flowers of Andryala glandulosa ssp. varia (Lowe ex DC.) R. Fern., an endemic species of Macaronesia region. Industrial crops and products, 42, 573-582.pt_PT
dc.identifier.doi10.1016/j.indcrop.2012.06.040pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3227
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationISOLAMENTO E CARACTERIZAÇÃO DE PRINCÍPIOS ACTIVOS DE PLANTAS PARA O COMBATE À TUBERCULOSE
dc.relationStrategic Project - UI 674 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAsteraceaept_PT
dc.subjectAndryalapt_PT
dc.subjectPolyphenolspt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectHPLC-DAD-ESI/MSnpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleCharacterization of phenolic compounds and antioxidant activity of ethanolic extracts from flowers of Andryala glandulosa ssp. varia (Lowe ex DC.) R.Fern., an endemic species of Macaronesia regionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleISOLAMENTO E CARACTERIZAÇÃO DE PRINCÍPIOS ACTIVOS DE PLANTAS PARA O COMBATE À TUBERCULOSE
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F24227%2F2005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.citation.endPage582pt_PT
oaire.citation.startPage573pt_PT
oaire.citation.titleIndustrial Crops and Productspt_PT
oaire.citation.volume42pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGouveia-Figueira
person.familyNameGonçalves
person.familyNameCastilho
person.givenNameSandra
person.givenNameJoão
person.givenNamePaula C
person.identifierA-4412-2013
person.identifier.ciencia-id8C14-3188-9E44
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0002-8116-2794
person.identifier.orcid0000-0002-1265-6686
person.identifier.orcid0000-0002-8303-4286
person.identifier.ridC-1348-2019
person.identifier.scopus-author-id52163735200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication7971c475-3f08-4462-96b1-79e96c9615a4
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relation.isAuthorOfPublication.latestForDiscovery7971c475-3f08-4462-96b1-79e96c9615a4
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