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Compound high-quality criteria: a new vision to guide the development of drugs, current situation

2016Journal article Restricted access
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dc.contributor.authorMignani, Serge
dc.contributor.authorHuber, Scot
dc.contributor.authorTomás, Helena
dc.contributor.authorRodrigues, João
dc.contributor.authorMajoral, Jean-Pierre
dc.date.accessioned2019-06-25T10:34:45Z
dc.date.available2019-06-25T10:34:45Z
dc.date.issued2016
dc.description.abstractFor several decades, the pharmaceutical industry has suffered due to major issues such as reductions of the number of FDA approved drugs and biologics. Several analyses have been highlighted that the 'druglikeness' is one of the strategies to improve succeed rates of screening such as, for instance, high-throughput screening (HTS), and then hits (as starting point), leads and clinical candidates. It is clear that the improvement of compound quality accelerates the drug discovery projects. The monitoring of several indices to avoid 'molecular obesity' (ADMET problems) of final drugs from good-quality 'low-fat' starting points represents today a powerful strategy of optimization process. The development of the new guides to find drugs highlighting attempts at improving the attrition rate from hits to final medicines by focusing on how to improve the druggability of hits, leads and drugs during the drug discovery process represents a key approach to design next better generation of medicines.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMignani, S., Huber, S., Tomas, H., Rodrigues, J., & Majoral, J. P. (2016). Compound high-quality criteria: a new vision to guide the development of drugs, current situation. Drug Discovery Today, 21(4), 573-584.pt_PT
dc.identifier.doi10.1016/j.drudis.2016.01.005pt_PT
dc.identifier.issn1359-6446
dc.identifier.urihttp://hdl.handle.net/10400.13/2428
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectDrug industrypt_PT
dc.subjectDevelopment of drugspt_PT
dc.subjectDrug discoverypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleCompound high-quality criteria: a new vision to guide the development of drugs, current situationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.endPage584pt_PT
oaire.citation.startPage573pt_PT
oaire.citation.titleDrug Discovery Todaypt_PT
oaire.citation.volume21(4)pt_PT
oaire.fundingStream5876
person.familyNameMignani
person.familyNameTomás
person.familyNameRodrigues
person.givenNameSerge
person.givenNameHelena
person.givenNameJoão
person.identifier556975
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.orcid0000-0002-1383-5256
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0003-4552-1953
person.identifier.ridE-5991-2010
person.identifier.ridB-6816-2008
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id9233278800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcabd0aa0-5827-4e97-889b-922136d2dd4b
relation.isAuthorOfPublication3a747114-6ab9-454b-985b-00cbf792e273
relation.isAuthorOfPublication53031fca-b2e7-4ce4-bda9-61e486da4547
relation.isAuthorOfPublication.latestForDiscoverycabd0aa0-5827-4e97-889b-922136d2dd4b
relation.isProjectOfPublicationec6bb904-b852-4300-a638-266ee44773f0
relation.isProjectOfPublication.latestForDiscoveryec6bb904-b852-4300-a638-266ee44773f0

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