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Ethiopian mitochondrial DNA heritage: tracking gene flow across and around the gate of tears

2004Journal article Open access
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dc.contributor.authorKivisild, Toomas
dc.contributor.authorReidla, Maere
dc.contributor.authorMetspalu, Ene
dc.contributor.authorRosa, Alexandra
dc.contributor.authorBrehm, António
dc.contributor.authorPennarun, Erwan
dc.contributor.authorParik, Jüri
dc.contributor.authorGeberhiwot, Tarekegn
dc.contributor.authorUsanga, Esien
dc.contributor.authorVillems, Richard
dc.date.accessioned2020-12-28T14:04:33Z
dc.date.available2020-12-28T14:04:33Z
dc.date.issued2004
dc.description.abstractApproximately 10 miles separate the Horn of Africa from the Arabian Peninsula at Bab-el-Mandeb (the Gate of Tears). Both historic and archaeological evidence indicate tight cultural connections, over millennia, between these two regions. High-resolution phylogenetic analysis of 270 Ethiopian and 115 Yemeni mitochondrial DNAs was performed in a worldwide context, to explore gene flow across the Red and Arabian Seas. Nine distinct subclades, including three newly defined ones, were found to characterize entirely the variation of Ethiopian and Yemeni L3 lineages. Both Ethiopians and Yemenis contain an almost-equal proportion of Eurasian-specific M and N and African-specific lineages and therefore cluster together in a multidimensional scaling plot between Near Eastern and sub-Saharan African populations. Phylogeographic identification of potential founder haplotypes revealed that approximately one-half of haplogroup L0-L5 lineages in Yemenis have close or matching counterparts in southeastern Africans, compared with a minor share in Ethiopians. Newly defined clade L6, the most frequent haplogroup in Yemenis, showed no close matches among 3,000 African samples. These results highlight the complexity of Ethiopian and Yemeni genetic heritage and are consistent with the introduction of maternal lineages into the South Arabian gene pool from different source populations of East Africa. A high proportion of Ethiopian lineages, significantly more abundant in the northeast of that country, trace their western Eurasian origin in haplogroup N through assorted gene flow at different times and involving different source populations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationKivisild, T., Reidla, M., Metspalu, E., Rosa, A., Brehm, A., Pennarun, E., ... & Villems, R. (2004). Ethiopian mitochondrial DNA heritage: tracking gene flow across and around the gate of tears. The American Journal of Human Genetics, 75(5), 752-770.pt_PT
dc.identifier.doi10.1086/425161pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3043
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCell Presspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBase sequencept_PT
dc.subjectDNA, Mitochondrialpt_PT
dc.subjectEthiopiapt_PT
dc.subjectEthnic groupspt_PT
dc.subjectEvolution, Molecularpt_PT
dc.subjectGeographypt_PT
dc.subjectHaplotypespt_PT
dc.subjectHumanspt_PT
dc.subjectMolecular sequence datapt_PT
dc.subjectPolymorphism, Restriction fragment lengthpt_PT
dc.subjectSequence analysis, DNApt_PT
dc.subjectYemenpt_PT
dc.subjectGenetic variationpt_PT
dc.subjectGenetics, Populationpt_PT
dc.subjectPhylogenypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleEthiopian mitochondrial DNA heritage: tracking gene flow across and around the gate of tearspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage770pt_PT
oaire.citation.startPage752pt_PT
oaire.citation.titleThe American Journal of Human Geneticspt_PT
oaire.citation.volume75(5)pt_PT
person.familyNameda Silva Rosa
person.familyNameBrehm
person.givenNamePatrícia Alexandra
person.givenNameAntonio
person.identifier.ciencia-idF01B-3B5B-2269
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0002-1827-6828
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-idAuthor ID 7006085833
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcc0e7b32-45ac-4aad-9256-32bc9de21975
relation.isAuthorOfPublication62d279e2-247a-4652-a370-3e8c2a846e31
relation.isAuthorOfPublication.latestForDiscovery62d279e2-247a-4652-a370-3e8c2a846e31

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