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Clinical effects of immersive multimodal BCI-VR training after bilateral neuromodulation with rTMS on upper limb motor recovery after stroke. a study protocol for a randomized controlled trial

2021Journal article Open access
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dc.contributor.authorSánchez Cuesta, Francisco José
dc.contributor.authorArroyo-Ferrer, Aida
dc.contributor.authorGonzález-Zamorano, Yeray
dc.contributor.authorVourvopoulos, Athanasios
dc.contributor.authorBermúdez i Badia, Sergi
dc.contributor.authorFigueiredo, Patricia
dc.contributor.authorSerrano, José Ignacio
dc.contributor.authorRomero, Juan Pablo
dc.date.accessioned2022-07-21T14:10:17Z
dc.date.available2022-07-21T14:10:17Z
dc.date.issued2021
dc.description.abstractThe motor sequelae after a stroke are frequently persistent and cause a high degree of disability. Cortical ischemic or hemorrhagic strokes affecting the cortico spinal pathways are known to cause a reduction of cortical excitability in the lesioned area not only for the local connectivity impairment but also due to a contralateral hemisphere inhibitory action. Non-invasive brain stimulation using high frequency repetitive magnetic transcranial stimulation (rTMS) over the lesioned hemisphere and contralateral cortical inhibition using low-frequency rTMS have been shown to increase the excitability of the lesioned hemisphere. Mental representation techniques, neurofeedback, and virtual reality have also been shown to increase cortical excitability and complement conventional rehabilitation. Materials and Methods: We aim to carry out a single-blind, randomized, controlled trial aiming to study the efficacy of immersive multimodal Brain–Computer Interfacing-Virtual Reality (BCI-VR) training after bilateral neuromodulation with rTMS on upper limb motor recovery after subacute stroke (>3 months) compared to neuromodulation combined with conventional motor imagery tasks. This study will include 42 subjects in a randomized controlled trial design. The main expected outcomes are changes in the Motricity Index of the Arm (MI), dynamometry of the upper limb, score according to Fugl-Meyer for upper limb (FMA-UE), and changes in the Stroke Impact Scale (SIS). The evaluation will be carried out before the intervention, after each intervention and 15 days after the last session. Conclusions: This trial will show the additive value of VR immersive motor imagery as an adjuvant therapy combined with a known effective neuromodulation approach opening new perspectives for clinical rehabilitation protocols.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSánchez-Cuesta, F. J., Arroyo-Ferrer, A., González-Zamorano, Y., Vourvopoulos, A., Badia, S. B. I., Figuereido, P., ... & Romero, J. P. (2021). Clinical effects of immersive multimodal BCI-VR training after bilateral neuromodulation with rTMS on upper limb motor recovery after stroke. a study protocol for a randomized controlled trial. Medicina, 57(8), 736.pt_PT
dc.identifier.doi10.3390/medicina57080736pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4445
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectStrokept_PT
dc.subjectRepetitive transcranial magnetic stimulationpt_PT
dc.subjectBCI-VR trainingpt_PT
dc.subjectMotor skillspt_PT
dc.subjectUper limbpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleClinical effects of immersive multimodal BCI-VR training after bilateral neuromodulation with rTMS on upper limb motor recovery after stroke. a study protocol for a randomized controlled trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.startPage736pt_PT
oaire.citation.titleMedicinapt_PT
oaire.citation.volume57pt_PT
person.familyNameSánchez Cuesta
person.familyNameArroyo
person.familyNameGonzález
person.familyNameVourvopoulos
person.familyNameBermúdez i Badia
person.familyNameFigueiredo
person.familyNameSerrano
person.familyNameRomero
person.givenNameFrancisco José
person.givenNameAida
person.givenNameYeray
person.givenNameAthanasios
person.givenNameSergi
person.givenNamePatricia
person.givenNameJ. Ignacio
person.givenNameJuan Pablo
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person.identifier.orcid0000-0002-3190-1296
person.identifier.ridF-3872-2017
person.identifier.ridC-8681-2018
person.identifier.ridA-1194-2013
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person.identifier.scopus-author-id48762198300
person.identifier.scopus-author-id6506360007
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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