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A comparative study of the biological properties of Eugenia uniflora L. fruits and leaves related to the prevention of cardiovascular diseases

2025-01-22Artigo científico Acesso aberto
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Naturais::Ciências Químicas
dc.contributor.authorGonçalves, Jéssica
dc.contributor.authorHontman, Nance
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorCâmara, José S.
dc.contributor.authorHontman, Nance
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorCâmara, José
dc.date.accessioned2025-09-02T09:09:14Z
dc.date.available2025-09-02T09:09:14Z
dc.date.issued2025-01-22
dc.description.abstract<jats:p>Cardiovascular diseases (CVDs) remain the leading cause of death globally, emphasizing the need for effective preventive strategies. Plant-based foods, rich in phytochemicals, offer a promising potential in CVD prevention. This study investigated the antioxidant, anti-inflammatory, and antihypertensive properties of two Eugenia uniflora L. varieties (orange and purple pitanga) and their leaves. Their antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation scavenging activity assays, while their antihypertensive activity was evaluated through angiotensin-converting enzyme (ACE) inhibition. Their anti-inflammatory potential was determined via protein denaturation inhibition. Both fruit varieties exhibited similar bioactivities, with the purple variety showing a slightly higher activity, except in the DPPH and ABTS assays. The leaves consistently demonstrated the lowest activities across all assays. Free polyphenols, dominated by gallic acid, were quantified using µ-QuEChERS followed by ultrahigh-performance liquid chromatography (UHPLC-PDA). The orange variety contained the highest concentration of gallic acid (13.1 mg/100 g DW). These findings highlight the potential of Eugenia uniflora L. extracts as natural antioxidant, anti-inflammatory, and antihypertensive agents, suggesting their value in food, pharmaceutical, and cosmetic applications for promoting human health and preventing CVDs.</jats:p>eng
dc.identifier.citationGonçalves, J.; Hontman, N.; Perestrelo, R.; Câmara, J.S. A Comparative Study of the Biological Properties of Eugenia uniflora L. Fruits and Leaves Related to the Prevention of Cardiovascular Diseases. Life 2025, 15, 147. https://doi.org/10.3390/ life15020147
dc.identifier.doi10.3390/life15020147
dc.identifier.issn2075-1729
dc.identifier.urihttp://hdl.handle.net/10400.13/7362
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.relation.ispartofLife
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEugenia uniflora L.
dc.subjectPolyphenols
dc.subjectBiological activities
dc.subjectCardiovascular diseases
dc.subject.
dc.subjectCentro de Química da Madeira
dc.subjectFaculdade de Ciências Exatas e da Engenharia
dc.titleA comparative study of the biological properties of Eugenia uniflora L. fruits and leaves related to the prevention of cardiovascular diseaseseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/00674/2020
oaire.awardNumberUIDP/00674/2020
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.issue2
oaire.citation.titleLife
oaire.citation.volume15
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameHontman
person.familyNamePerestrelo
person.familyNameCâmara
person.givenNameNance
person.givenNameRosa
person.givenNameJosé
person.identifier1441319
person.identifierG-3003-2013
person.identifier.ciencia-id251A-D5F7-9E32
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.orcid0000-0003-4125-6312
person.identifier.orcid0000-0002-7223-1022
person.identifier.orcid0000-0003-1965-3151
person.identifier.ridI-2307-2014
person.identifier.scopus-author-id16686828800
person.identifier.scopus-author-id10140393000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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