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A glance over doxorubicin based-nanotherapeutics: from proof-of-concept studies to solutions in the market

2020Journal article Open access
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dc.contributor.authorGonçalves, Mara
dc.contributor.authorMignani, Serge
dc.contributor.authorRodrigues, João
dc.contributor.authorTomás, Helena
dc.date.accessioned2021-09-22T09:11:04Z
dc.date.available2021-09-22T09:11:04Z
dc.date.issued2020
dc.description.abstractCancer is one of the leading causes of death worldwide and, as such, efforts are being done to find new che motherapeutic drugs or, alternatively, novel approaches for the delivery of old ones. In this scope, when used as vehicles for drugs, nanomaterials may potentially maximize the efficacy of the treatment and reduce its side effects, for example by a change in drug's pharmacokinetics, cell targeting and/or specific stimuli-responsive ness. This is the case of doxorubicin (DOX) that presents a broad spectrum of activity and is one of the most widely used chemotherapeutic drugs as first-line treatment. Indeed, DOX is a very interesting example of a drug for which several nanosized delivery systems have been developed over the years. While it is true that some of these systems are already in the market, it is also true that research on this subject remains very active and that there is a continuing search for new solutions. In this sense, this review takes the example of doxorubicin, not so much with the focus on the drug itself, but rather as a case study around which very diverse and imaginative nanotechnology approaches have emerged.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves, M., Mignani, S., Rodrigues, J., & Tomás, H. (2020). A glance over doxorubicin based-nanotherapeutics: from proof-of-concept studies to solutions in the market. Journal of Controlled Release, 317, 347-374. https://doi.org/10.1016/j.jconrel.2019.11.016pt_PT
dc.identifier.doi10.1016/j.jconrel.2019.11.016pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3650
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCancerpt_PT
dc.subjectChemotherapypt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectNanotherapeuticspt_PT
dc.subjectDelivery systemspt_PT
dc.subjectClinical trialspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleA glance over doxorubicin based-nanotherapeutics: from proof-of-concept studies to solutions in the marketpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F88721%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00674%2F2019/PT
oaire.citation.endPage374pt_PT
oaire.citation.startPage347pt_PT
oaire.citation.titleJournal of Controlled Releasept_PT
oaire.citation.volume317pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGonçalves
person.familyNameMignani
person.familyNameRodrigues
person.familyNameTomás
person.givenNameMara
person.givenNameSerge
person.givenNameJoão
person.givenNameHelena
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person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-7856-2041
person.identifier.ridB-6816-2008
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person.identifier.scopus-author-id55509603000
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id6508104177
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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