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Differences in the volatilomic urinary biosignature of prostate cancer patients as a feasibility study for the detection of potential biomarkers

2023-05-10Journal article Open access
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datacite.subject.fosCiências Médicas::Biotecnologia Médica
datacite.subject.fosEngenharia e Tecnologia::Engenharia Médica
dc.contributor.authorRiccio, Giulia
dc.contributor.authorBerenguer, Cristina V.
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorPereira, Ferdinando
dc.contributor.authorBerenguer, Pedro
dc.contributor.authorOrnelas, Cristina P.
dc.contributor.authorSousa, Ana Célia
dc.contributor.authorVital, João Aragão
dc.contributor.authorPinto, Maria do Carmo
dc.contributor.authorPereira, Jorge A. M.
dc.contributor.authorGreco, Viviana
dc.contributor.authorCâmara, José S.
dc.contributor.authorBerenguer, Cristina
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorAugusto Machado Pereira, Jorge
dc.contributor.authorCâmara, José
dc.date.accessioned2025-06-17T10:29:32Z
dc.date.available2025-06-17T10:29:32Z
dc.date.issued2023-05-10
dc.description.abstract<jats:p>Prostate cancer (PCa) continues to be the second most common malignant tumour and the main cause of oncological death in men. Investigating endogenous volatile organic metabolites (VOMs) produced by various metabolic pathways is emerging as a novel, effective, and non-invasive source of information to establish the volatilomic biosignature of PCa. In this study, headspace solid-phase microextraction combined with gas chromatography–mass spectrometry (HS-SPME/GC-MS) was used to establish the urine volatilomic profile of PCa and identify VOMs that can discriminate between the two investigated groups. This non-invasive approach was applied to oncological patients (PCa group, n = 26) and cancer-free individuals (control group, n = 30), retrieving a total of 147 VOMs from various chemical families. This included terpenes, norisoprenoid, sesquiterpenes, phenolic, sulphur and furanic compounds, ketones, alcohols, esters, aldehydes, carboxylic acid, benzene and naphthalene derivatives, hydrocarbons, and heterocyclic hydrocarbons. The data matrix was subjected to multivariate analysis, namely partial least-squares discriminant analysis (PLS-DA). Accordingly, this analysis showed that the group under study presented different volatomic profiles and suggested potential PCa biomarkers. Nevertheless, a larger cohort of samples is required to boost the predictability and accuracy of the statistical models developed.</jats:p>eng
dc.identifier.citationRiccio, G.; Berenguer, C.V.; Perestrelo, R.; Pereira, F.; Berenguer, P.; Ornelas, C.P.; Sousa, A.C.; Vital, J.A.; Pinto, M.d.C.; Pereira, J.A.M.; et al. Differences in the Volatilomic Urinary Biosignature of Prostate Cancer Patients as a Feasibility Study for the Detection of Potential Biomarkers. Curr. Oncol. 2023, 30, 4904–4921. https://doi.org/10.3390/ curroncol30050370
dc.identifier.doi10.3390/curroncol30050370
dc.identifier.issn1718-7729
dc.identifier.urihttp://hdl.handle.net/10400.13/7310
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.relation.ispartofCurrent Oncology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectProstate cancer
dc.subjectVolatilomics
dc.subjectUrine
dc.subjectBiomarkers
dc.subject.
dc.subjectCentro de Química da Madeira
dc.subjectFaculdade de Ciências Exatas e da Engenharia
dc.titleDifferences in the volatilomic urinary biosignature of prostate cancer patients as a feasibility study for the detection of potential biomarkerseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.issue5
oaire.citation.titleCurrent Oncology
oaire.citation.volume30
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBerenguer
person.familyNamePerestrelo
person.familyNameAugusto Machado Pereira
person.familyNameCâmara
person.givenNameCristina
person.givenNameRosa
person.givenNameJorge
person.givenNameJosé
person.identifier1441319
person.identifierG-3003-2013
person.identifier.ciencia-id251A-D5F7-9E32
person.identifier.ciencia-idEC12-EE8F-50E8
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.orcid0000-0002-1762-1175
person.identifier.orcid0000-0002-7223-1022
person.identifier.orcid0000-0003-0316-5348
person.identifier.orcid0000-0003-1965-3151
person.identifier.ridI-2307-2014
person.identifier.scopus-author-id16686828800
person.identifier.scopus-author-id10140393000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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