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- A fast responsive chromogenic and near-infrared fluorescence lighting-up probe for visual detection of toxic thiophenol in environmental water and living cellsPublication . Wu, Juanjuan; Su, Dongdong; Qin, Caiqin; Li, Wei; Rodrigues, João; Sheng, Ruilong; Zeng, LintaoThiophenols as high toxic environmental pollutants are poisonous for animals and aquatic organisms. Therefore, it is indispensable to monitor thiophenols in the environment. Herein, a novel near-infrared fluorescent probe was developed for the detection of thiophenols, which was easily prepared by one-step coupling of 2,4-dini trobenzenesulfonyl chloride with Nile blue. The probe showed a significant near infrared (∼675 nm) fluores cence “turn-on” response to thiophenols with some good features including chromogenic reaction, high sensi tivity and selectivity, fast response, near-infrared emission along with low detection limit (1.8 nM). The probe was employed to rapidly and visually determine thiophenols in several industrial wastewaters with good re coveries (90–110%). Moreover, this probe has been demonstrated good capability for imaging thiophenol in HeLa cells
- Chemical sensors towards environmental toxic molecule monitoring: fluorescent probes for detection of thiophenolPublication . Jiang, Lirong; Wu, Juanjuan; Min, Douyong; Rodrigues, João; Sheng, RuilongThiophenols, a family of important industrial chemicals, is highly toxic for aquatic organisms and human beings. Developing new chemical sensors with the merit of fast, low cost, portable, selective and sensitive, as well as visualizable signal output for efficient detection of thiophenols, is highly desirable. This spotlight article reviewed and discussed the current trend and statement of thiophenols-specific fluorescent probes. Moreover, the future outlook in this field was also stated.
- A selective cascade reaction-based probe for colorimetric and ratiometric fluorescence detection of benzoyl peroxide in food and living cellsPublication . Wu, Xiaoli; Zeng, Lintao; Chen, Bao-Quan; Zhang, Ming; Rodrigues, João; Sheng, Ruilong; Bao, Guang-MingA novel colorimetric and ratiometric fluorescent probe (Cou-BPO) was readily prepared for specific detection of harmful benzoyl peroxide (BPO). The probe Cou-BPO reacted with BPO via a selective oxidation cleavage-induced cascade reaction of the pinacol phenylboronate group, which resulted in an observable colorimetric and ratiometric fluorescence response towards BPO with a fast response time (o15 min) and a low detection limit (56 nM). For practical application, facile, portable and sensitive test paper of Cou-BPO has been prepared for visual detection of BPO. Furthermore, we employed Cou-BPO as a probe to determine BPO in food samples and living cells.
- A dual-analytes responsive fluorescent probe for discriminative detection of ClO− and N2H4 in living cellsPublication . Zhu, Beitong; Wu, Xiaoli; Rodrigues, João; Hu, Xichao; Sheng, Ruilong; Bao, Guang-MingHydrazine (N2H4) and ClO− are very harmful for public health, hence it is important and necessary to monitor them in living cells. Herein, we rationally designed and synthesized a dual-analytes responsive fluorescent sensor PTMQ for distinguishing detection of N2H4 and ClO−. PTMQ underwent N2H4-induced double bond cleavage, affording colorimetric and green fluorescence enhancement with good selectivity and a low detection limit (89 nM). On the other hand, PTMQ underwent ClO−-induced sulfur oxidation and displayed red fluorescence lighting-up response towards ClO− with good selectivity, rapid response (<0.2 min) and a low detection limit (58 nM). Moreover, PTMQ was successfully employed for in-situ imaging of N2H4 and ClO− in living cells
- Polysaccharide-based nanomedicines for cancer immunotherapy: a reviewPublication . Zeng, Yujun; Xiang, Yufan; Sheng, Ruilong; Tomás, Helena; Rodrigues, João; Gu, Zhongwei; Zhang, Hu; Gong, Qiyong; Luo, KuiCancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics. However, direct administration of “naked” immunotherapeutic agents (such as nucleic acids, cytokines, adjuvants or antigens without delivery vehicles) often results in: (1) an unsatisfactory efficacy due to suboptimal pharmacokinetics; (2) strong toxic and side effects due to low targeting (or off-target) efficiency. To overcome these shortcomings, a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects. Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties, as they could interact with immune system to stimulate an enhanced immune response. Their structures offer versatility in synthesizing multifunctional nanocomposites, which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues. This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics.