A carregar...
Publicação
Polysaccharide-based nanomedicines for cancer immunotherapy: a review
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 10.98 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate
tumors by immunotherapeutics. However, direct administration of “naked” immunotherapeutic agents (such as
nucleic acids, cytokines, adjuvants or antigens without delivery vehicles) often results in: (1) an unsatisfactory
efficacy due to suboptimal pharmacokinetics; (2) strong toxic and side effects due to low targeting (or off-target)
efficiency. To overcome these shortcomings, a series of polysaccharide-based nanoparticles have been developed
to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects.
Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties, as
they could interact with immune system to stimulate an enhanced immune response. Their structures offer
versatility in synthesizing multifunctional nanocomposites, which could be chemically modified to achieve high
stability and bioavailability for delivering therapeutics into tumor tissues. This review aims to highlight recent
advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on
the use of polysaccharide-based immunotherapeutics.
Descrição
Palavras-chave
Polysaccharides Drug delivery systems Nanomedicines Cancer immunotherapy Anticancer efficacy . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Contexto Educativo
Citação
Zeng, Y., Xiang, Y., Sheng, R., Tomás, H., Rodrigues, J., Gu, Z., ... & Luo, K. (2021). Polysaccharide-based nanomedicines for cancer immunotherapy: a review. Bioactive Materials, 6(10), 3358-3382. https://doi.org/10.1016/j.bioactmat.2021.03.008
Editora
Elsevier