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Polysaccharide-based nanomedicines for cancer immunotherapy: a review

2021Journal article Open access
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dc.contributor.authorZeng, Yujun
dc.contributor.authorXiang, Yufan
dc.contributor.authorSheng, Ruilong
dc.contributor.authorTomás, Helena
dc.contributor.authorRodrigues, João
dc.contributor.authorGu, Zhongwei
dc.contributor.authorZhang, Hu
dc.contributor.authorGong, Qiyong
dc.contributor.authorLuo, Kui
dc.date.accessioned2022-02-15T09:05:56Z
dc.date.available2022-02-15T09:05:56Z
dc.date.issued2021
dc.description.abstractCancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics. However, direct administration of “naked” immunotherapeutic agents (such as nucleic acids, cytokines, adjuvants or antigens without delivery vehicles) often results in: (1) an unsatisfactory efficacy due to suboptimal pharmacokinetics; (2) strong toxic and side effects due to low targeting (or off-target) efficiency. To overcome these shortcomings, a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects. Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties, as they could interact with immune system to stimulate an enhanced immune response. Their structures offer versatility in synthesizing multifunctional nanocomposites, which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues. This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZeng, Y., Xiang, Y., Sheng, R., Tomás, H., Rodrigues, J., Gu, Z., ... & Luo, K. (2021). Polysaccharide-based nanomedicines for cancer immunotherapy: a review. Bioactive Materials, 6(10), 3358-3382. https://doi.org/10.1016/j.bioactmat.2021.03.008pt_PT
dc.identifier.doi10.1016/j.bioactmat.2021.03.008pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4080
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolysaccharidespt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectNanomedicinespt_PT
dc.subjectCancer immunotherapypt_PT
dc.subjectAnticancer efficacypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titlePolysaccharide-based nanomedicines for cancer immunotherapy: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.citation.endPage3382pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage3358pt_PT
oaire.citation.titleBioactive Materialspt_PT
oaire.citation.volume6pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSheng
person.familyNameTomás
person.familyNameRodrigues
person.givenNameRuilong
person.givenNameHelena
person.givenNameJoão
person.identifierhttps://scholar.google.ca/citations?user=YCheaFsAAAAJ&hl=en
person.identifier556975
person.identifier.ciencia-idC019-C809-403B
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person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.orcid0000-0002-3303-3832
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0003-4552-1953
person.identifier.ridE-5991-2010
person.identifier.ridB-6816-2008
person.identifier.scopus-author-id7005472737
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id9233278800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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