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- Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cellsPublication . Li, Aijun; Fan, Yu; Cao, Xueyan; Chen, Liang; Wang, Le; Alves, Carla S.; Mignani, Serge; Majoral, Jean Pierre; Tomás, Helena; Shi, XiangyangA novel bioactive macromolecule based on morpholino-functiona lized phosphorus dendrimers (generation 2, G2-Mor+ ) was devel oped for osteogenic differentiation of mesenchymal stem cells (MSCs). Interestingly, through in vitro tests, it was shown that G2- Mor+ dendrimer can strongly promote the transformation of MSCs into osteoblasts, which implies the potential application of phos phorus de medicine.
- Dendrimers toward translational nanotherapeutics: concise key step analysisPublication . Mignani, Serge; Shi, Xiangyang; Rodrigues, João; Roy, René; Muñoz-Fernández, Ángeles; Ceña, Valentin; Majoral, Jean PierreThe goal of nanomedicine is to address specific clinical problems optimally, to fight human diseases, and to find clinical relevance to change clinical practice. Nanomedicine is poised to revolutionize medicine via the development of more precise diagnostic and therapeutic tools. The field of nanomedicine encompasses numerous features and therapeutic disciplines. A plethora of nanomolecular structures have been engineered and developed for therapeutic applications based on their multitasking abilities and the wide functionalization of their core scaffolds and surface groups. Within nanoparticles used for nanomedicine, dendrimers as well polymers have demonstrated strong potential as nanocarriers, therapeutic agents, and imaging contrast agents. In this review, we present and discuss the different criteria and parameters to be addressed to prepare and develop druggable nanoparticles in general and dendrimers in particular. We also describe the major requirements, included in the preclinical and clinical roadmap, for NPs/dendrimers for the preclinical stage to commercialization. Ultimately, we raise the clinical translation of new nanomedicine issues.
- Synthesis of onion‐peel nanodendritic structures with sequential functional phosphorus diversityPublication . Katir, Nadia; El Brahmi, Nabil; El Kadib, Abdelkrim; Mignani, Serge; Caminade, Anne‐Marie; Bousmina, Mosto; Majoral, Jean PierreThe preparation of novel families of phosphorus based macromolecular architectures called “onion peel” phosphorus nanodendritic systems is reported. This con struct is based on the versatility of methods of synthesis using several building blocks and on the capability of these systems to undergo regioselective reactions within the cas cade structure. Sustainable metal-free routes such as the Staudinger reaction or Schiff-base condensation, involving only water and nitrogen as byproducts, allow access to sev eral dendritic macromolecules bearing up to seven different phosphorus units in their backbone, each of them featuring specific reactivity. The presence of the highly aurophilic P= N¢P=S fragment enables selective ligation of Au I within the dendritic framework.