Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells

A novel bioactive macromolecule based on morpholino-functiona lized phosphorus dendrimers (generation 2, G2-Mor+ ) was devel oped for osteogenic differentiation of mesenchymal stem cells (MSCs). Interestingly, through in vitro tests, it was shown that G2- Mor+ dendrimer can strongly promote the transformation of MSCs into osteoblasts, which implies the potential application of phos phorus de medicine.

Keywords

Morpholino-functionalized phosphorus dendrimers Precision regenerative medicine Osteogenic differentiation Mesenchymal stem cells . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira

URI

http://hdl.handle.net/10400.13/4328

Citation

Li, A., Fan, Y., Cao, X., Chen, L., Wang, L., Alves, C. S., ... & Shi, X. (2019). Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells. Nanoscale, 11(37), 17230-17234. DOI: 10.1039/C9NR06410A