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Publication
Dendrimers toward translational nanotherapeutics: concise key step analysis
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| 3.33 MB | Adobe PDF |
Advisor(s)
Abstract(s)
The goal of nanomedicine is to address specific
clinical problems optimally, to fight human diseases, and to find
clinical relevance to change clinical practice. Nanomedicine is
poised to revolutionize medicine via the development of more
precise diagnostic and therapeutic tools. The field of nanomedicine
encompasses numerous features and therapeutic disciplines. A
plethora of nanomolecular structures have been engineered and
developed for therapeutic applications based on their multitasking
abilities and the wide functionalization of their core scaffolds and
surface groups. Within nanoparticles used for nanomedicine,
dendrimers as well polymers have demonstrated strong potential as
nanocarriers, therapeutic agents, and imaging contrast agents. In
this review, we present and discuss the different criteria and parameters to be addressed to prepare and develop druggable
nanoparticles in general and dendrimers in particular. We also describe the major requirements, included in the preclinical and
clinical roadmap, for NPs/dendrimers for the preclinical stage to commercialization. Ultimately, we raise the clinical translation of
new nanomedicine issues.
Description
Keywords
Nanomedicine Dendrimers Translational nanotherapeutics Nanotherapeutics . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Citation
Mignani, S., Shi, X., Rodrigues, J., Roy, R., Muñoz-Fernández, Á., Ceña, V., & Majoral, J. P. (2020). Dendrimers toward translational nanotherapeutics: concise key step analysis. Bioconjugate Chemistry, 31(9), 2060-2071. https://doi.org/10.1021/acs.bioconjchem.0c00395
Publisher
American Chemical Society