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Dendrimers toward translational nanotherapeutics: concise key step analysis

2020Journal article Open access
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dc.contributor.authorMignani, Serge
dc.contributor.authorShi, Xiangyang
dc.contributor.authorRodrigues, João
dc.contributor.authorRoy, René
dc.contributor.authorMuñoz-Fernández, Ángeles
dc.contributor.authorCeña, Valentin
dc.contributor.authorMajoral, Jean Pierre
dc.date.accessioned2022-02-18T11:36:40Z
dc.date.available2022-02-18T11:36:40Z
dc.date.issued2020
dc.description.abstractThe goal of nanomedicine is to address specific clinical problems optimally, to fight human diseases, and to find clinical relevance to change clinical practice. Nanomedicine is poised to revolutionize medicine via the development of more precise diagnostic and therapeutic tools. The field of nanomedicine encompasses numerous features and therapeutic disciplines. A plethora of nanomolecular structures have been engineered and developed for therapeutic applications based on their multitasking abilities and the wide functionalization of their core scaffolds and surface groups. Within nanoparticles used for nanomedicine, dendrimers as well polymers have demonstrated strong potential as nanocarriers, therapeutic agents, and imaging contrast agents. In this review, we present and discuss the different criteria and parameters to be addressed to prepare and develop druggable nanoparticles in general and dendrimers in particular. We also describe the major requirements, included in the preclinical and clinical roadmap, for NPs/dendrimers for the preclinical stage to commercialization. Ultimately, we raise the clinical translation of new nanomedicine issues.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMignani, S., Shi, X., Rodrigues, J., Roy, R., Muñoz-Fernández, Á., Ceña, V., & Majoral, J. P. (2020). Dendrimers toward translational nanotherapeutics: concise key step analysis. Bioconjugate Chemistry, 31(9), 2060-2071. https://doi.org/10.1021/acs.bioconjchem.0c00395pt_PT
dc.identifier.doi10.1021/acs.bioconjchem.0c00395pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4092
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNanomedicinept_PT
dc.subjectDendrimerspt_PT
dc.subjectTranslational nanotherapeuticspt_PT
dc.subjectNanotherapeuticspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleDendrimers toward translational nanotherapeutics: concise key step analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.endPage2071pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage2060pt_PT
oaire.citation.titleBioconjugate Chemistrypt_PT
oaire.citation.volume31pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMignani
person.familyNameShi
person.familyNameRodrigues
person.familyNameRoy
person.familyNameMuñoz-Fernández
person.familyNameCeña
person.familyNameMajoral
person.givenNameSerge
person.givenNameXiangyang
person.givenNameJoão
person.givenNameRené
person.givenNameMª Ángeles
person.givenNameValentin
person.givenNameJean Pierre
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person.identifier.scopus-author-id25931106800
person.identifier.scopus-author-id56269211900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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