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Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex

2022Journal article Open access
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dc.contributor.authorNesic, Maja D.
dc.contributor.authorDucic, Tanja
dc.contributor.authorGonçalves, Mara
dc.contributor.authorStepić, Milutin
dc.contributor.authorAlgarra, Manuel
dc.contributor.authorSoto, Juan
dc.contributor.authorGemović, Branislava
dc.contributor.authorBandosz, Teresa J.
dc.contributor.authorPetkovic, Marijana
dc.date.accessioned2023-06-19T10:51:31Z
dc.date.available2023-06-19T10:51:31Z
dc.date.issued2022
dc.description.abstractCarbon dots (CDs) and N-carbon dots (N-CDs) loaded with Ru-complex (CDs@RuCN, N-CDs@RuCN, respec tively) were investigated as media imposing biochemical changes induced by UV illumination of ovarian cancer, A2780, and osteosarcoma, CAL72, cells. Synchrotron radiation-based Fourier Transform Infrared Spectroscopy was performed, and the spectra were subjected to a Principal Component Analysis. The CDs@RuCN and N CDs@RuCN effects on cancer cells were analyzed by the theoretical modelling of the stability of the composite systems and a protein database search. Moreover, a detailed evaluation of surface and optical properties of CDs@RuCN and N-CDs@RuCN was carried out. Results demonstrated selective action of the CDs@RuCN and N CDs@RuCN-based photodynamic therapy, with N-CDs@RuCN being the most active in inducing changes in A2780 and CDs@RuCN in CAL72 cells. We assume that different surface charges of nanoparticles led to direct interactions of N-CDs@RuCN with a Wnt signalling pathway in A2780 and those of CDs@RuCN with PI3–K/Akt in CAL72 cells and that further biochemical changes occurred upon light illumination.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNešić, M. D., Dučić, T., Gonçalves, M., Stepić, M., Algarra, M., Soto, J., ... & Petković, M. (2022). Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex. Chemico-Biological Interactions, 360, 109950.pt_PT
dc.identifier.doi10.1016/j.cbi.2022.109950pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5234
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnticancer photodynamic therapypt_PT
dc.subjectBiochemical changespt_PT
dc.subjectN-doped carbon dotspt_PT
dc.subjectCarbon dotspt_PT
dc.subjectRu-metallodrugpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleBiochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complexpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.startPage109950pt_PT
oaire.citation.titleChemico-Biological Interactionspt_PT
oaire.citation.volume360pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameNesic
person.familyNameDucic
person.familyNameGonçalves
person.familyNameAlgarra
person.familyNamePetkovic
person.givenNameMaja
person.givenNameTanja
person.givenNameMara
person.givenNameManuel
person.givenNameMarijana
person.identifierC-5257-2008
person.identifier.ciencia-id3011-173A-EBBC
person.identifier.ciencia-id6010-1863-4B11
person.identifier.ciencia-idF911-74AF-6932
person.identifier.ciencia-idAD15-C921-5954
person.identifier.orcid0000-0002-9167-6553
person.identifier.orcid0000-0003-2389-3887
person.identifier.orcid0000-0002-0332-3548
person.identifier.orcid0000-0003-2410-8430
person.identifier.orcid0000-0002-8354-995X
person.identifier.ridF-5107-2019
person.identifier.ridH-5567-2016
person.identifier.scopus-author-id56559929100
person.identifier.scopus-author-id55509603000
person.identifier.scopus-author-id6602455238
person.identifier.scopus-author-id7006986199
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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