Bioinspired superhydrophobic poly(L-lactic acid) surfaces control bone marrow derived cells adhesion and proliferation

Alves, Natália M.; Shi, Jun; Oramas, Elena; Santos, José L.; Tomás, Helena; Mano, João F.

http://hdl.handle.net/10400.13/2466

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Bioinspired superhydrophobic poly(L-lactic acid) surfaces prevent the adhesion and proliferation of bone marrow derived cells.pdf		315.77 KB	Adobe PDF	Download

Send Feedback

Authors

Abstract(s)

The aptitude of a cell to adhere, migrate, and differentiate on a compact substrate or scaffold is important in the field of tissue engineering and biomaterials. It is well known that cell behavior can be controlled and guided through the change in micro- and nano-scale topographic features. In this work, we intend to demonstrate that special topographic features that control wettability may also have an important role in the biological performance of biodegradable substrates. Poly(L-lactic acid) surfaces with superhydrophobic characteristics were produced, based on the so-called Lotus effect, exhibiting dual micro- and nano-scale roughness. The water contact angle could be higher than 150 degrees and a value of that order could be kept even upon immersion in a simulated body fluid solution for more than 20 days. Such water repellent surfaces were found to prevent adhesion and proliferation of bone marrow derived cells previously isolated from the femurs of 6-week-old male Wistar rats, when compared with smoother surfaces prepared by simple solvent casting. Such results demonstrate that these superhydrophobic surfaces may be used to control cell behavior onto biodegradable substrates.

Keywords

Surface roughness Wettability Cell adhesion Cell proliferation Poly(lactic acid) . Faculdade de Ciências Exatas e da Engenharia

URI

http://hdl.handle.net/10400.13/2466

Citation

Alves, N. M., Shi, J., Oramas, E., Santos, J. L., Tomás, H., & Mano, J. F. (2009). Bioinspired superhydrophobic poly (L‐lactic acid) surfaces control bone marrow derived cells adhesion and proliferation. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 91(2), 480-488.