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Bioinspired superhydrophobic poly(L-lactic acid) surfaces control bone marrow derived cells adhesion and proliferation

2009Journal article Restricted access
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dc.contributor.authorAlves, Natália M.
dc.contributor.authorShi, Jun
dc.contributor.authorOramas, Elena
dc.contributor.authorSantos, José L.
dc.contributor.authorTomás, Helena
dc.contributor.authorMano, João F.
dc.date.accessioned2019-07-09T10:53:37Z
dc.date.available2019-07-09T10:53:37Z
dc.date.issued2009
dc.description.abstractThe aptitude of a cell to adhere, migrate, and differentiate on a compact substrate or scaffold is important in the field of tissue engineering and biomaterials. It is well known that cell behavior can be controlled and guided through the change in micro- and nano-scale topographic features. In this work, we intend to demonstrate that special topographic features that control wettability may also have an important role in the biological performance of biodegradable substrates. Poly(L-lactic acid) surfaces with superhydrophobic characteristics were produced, based on the so-called Lotus effect, exhibiting dual micro- and nano-scale roughness. The water contact angle could be higher than 150 degrees and a value of that order could be kept even upon immersion in a simulated body fluid solution for more than 20 days. Such water repellent surfaces were found to prevent adhesion and proliferation of bone marrow derived cells previously isolated from the femurs of 6-week-old male Wistar rats, when compared with smoother surfaces prepared by simple solvent casting. Such results demonstrate that these superhydrophobic surfaces may be used to control cell behavior onto biodegradable substrates.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves, N. M., Shi, J., Oramas, E., Santos, J. L., Tomás, H., & Mano, J. F. (2009). Bioinspired superhydrophobic poly (L‐lactic acid) surfaces control bone marrow derived cells adhesion and proliferation. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 91(2), 480-488.pt_PT
dc.identifier.doi10.1002/jbm.a.32210pt_PT
dc.identifier.issn1549-3296
dc.identifier.urihttp://hdl.handle.net/10400.13/2466
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectSurface roughnesspt_PT
dc.subjectWettabilitypt_PT
dc.subjectCell adhesionpt_PT
dc.subjectCell proliferationpt_PT
dc.subjectPoly(lactic acid)pt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleBioinspired superhydrophobic poly(L-lactic acid) surfaces control bone marrow derived cells adhesion and proliferationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCI%2FFIS%2F61621%2F2004/PT
oaire.citation.endPage488pt_PT
oaire.citation.startPage480pt_PT
oaire.citation.titleJournal of Biomedical Materials Research Part Apt_PT
oaire.citation.volume91(2)pt_PT
oaire.fundingStreamPOCI
person.familyNameTomás
person.givenNameHelena
person.identifier556975
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0002-7856-2041
person.identifier.ridE-5991-2010
person.identifier.scopus-author-id6508104177
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3a747114-6ab9-454b-985b-00cbf792e273
relation.isAuthorOfPublication.latestForDiscovery3a747114-6ab9-454b-985b-00cbf792e273
relation.isProjectOfPublicationb0135cda-ad74-4066-a7be-1c751b232fb5
relation.isProjectOfPublication.latestForDiscoveryb0135cda-ad74-4066-a7be-1c751b232fb5

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