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Non-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regeneration

2011Journal article Restricted access
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dc.contributor.authorSantos, José L.
dc.contributor.authorPandita, Deepti
dc.contributor.authorRodrigues, João
dc.contributor.authorPêgo, Ana P.
dc.contributor.authorGranja, Pedro L.
dc.contributor.authorTomás, Helena
dc.date.accessioned2019-06-18T10:14:05Z
dc.date.available2019-06-18T10:14:05Z
dc.date.issued2011
dc.description.abstractMesenchymal stem cells (MSCs) can be isolated from several tissues in the body, have the ability to selfrenewal, show immune suppressive properties and are multipotent, being able to generate various cell types. At present, due to their intrinsic characteristics, MSCs are considered very promising in the area of tissue engineering and regenerative medicine. In this context, genetic modification can be a powerful tool to control the behavior and fate of these cells and be used in the design of new cellular therapies. Viral systems are very effective in the introduction of exogenous genes inside MSCs. However, the risks associated with their use are leading to an increasing search for non-viral approaches to attain the same purpose, even if MSCs have been shown to be more difficult to transfect in this way. In the past few years, progress was made in the development of chemical and physical methods for non-viral gene delivery. Herein, an overview of the application of those methods specifically to MSCs is given and their use in tissue engineering and regenerative medicine therapeutic strategies highlighted using the example of bone tissue. Key issues and future directions in non-viral gene delivery to MSCs are also critically addressed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, J. L., Pandita, D., Rodrigues, J., Pego, A. P., Granja, P. L., & Tomás, H. (2011). Non-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regeneration. Current gene therapy, 11(1), 46-57.pt_PT
dc.identifier.issn1566-5232
dc.identifier.urihttp://hdl.handle.net/10400.13/2402
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relationNOVEL DRUG/GENE DELIVERY PLATFORMS BASED ON THE SELF-ASSEMBLY OF DENDRIMER-SINGLE STRAND DNA CONJUGATES
dc.subjectBone tissue engineeringpt_PT
dc.subjectBone regenerationpt_PT
dc.subjectGene deliverypt_PT
dc.subjectMesenchymal stem cellspt_PT
dc.subjectNanomedicinept_PT
dc.subjectNon-viral vectorspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleNon-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNOVEL DRUG/GENE DELIVERY PLATFORMS BASED ON THE SELF-ASSEMBLY OF DENDRIMER-SINGLE STRAND DNA CONJUGATES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-BEB%2F71161%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F19450%2F2004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PIDDAC/SFRH%2FBPD%2F44821%2F2008/PT
oaire.citation.endPage57pt_PT
oaire.citation.startPage46pt_PT
oaire.citation.titleCurrent Gene Therapypt_PT
oaire.citation.volume11(1)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
oaire.fundingStreamPIDDAC
person.familyNameRodrigues
person.familyNamePêgo
person.familyNameTomás
person.givenNameJoão
person.givenNameAna Paula
person.givenNameHelena
person.identifier164495
person.identifier556975
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id6114-92F0-E64C
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0001-5169-328X
person.identifier.orcid0000-0002-7856-2041
person.identifier.ridB-6816-2008
person.identifier.ridC-6942-2012
person.identifier.ridE-5991-2010
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id56053889300
person.identifier.scopus-author-id6508104177
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery905a2f89-0018-47d3-850d-4b09bed65b5f
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