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Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

2014Journal article Open access
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dc.contributor.authorRamalhete, Cátia
dc.contributor.authorCruz, Filipa P. da
dc.contributor.authorMulhovo, Silva
dc.contributor.authorSousa, Inês J.
dc.contributor.authorFernandes, Miguel X.
dc.contributor.authorPrudêncio, Miguel
dc.contributor.authorFerreira, Maria-José U.
dc.date.accessioned2023-02-13T10:13:58Z
dc.date.available2023-02-13T10:13:58Z
dc.date.issued2014
dc.description.abstractSixteen triterpenoids (1–16), previously isolated from the aerial parts of the African medicinal plant Momordica balsamina or obtained by derivatization, were evaluated for their activity against liver stages of Plasmodium berghei, measuring the luminescence intensity in Huh-7 cells infected with a firefly lucif erase-expressing P. berghei line, PbGFP-Luccon. Toxicity of compounds (1–16) was assessed on the same cell line through the fluorescence measurement of cell confluency. The highest activity was displayed by a derivative bearing two acetyl residues, karavoate B (7), which led to a dose-dependent decrease in the P. berghei infection rate, exhibiting a very significant activity at the lowest concentration employed (1 lM) and no toxicity towards the Huh-7 cells. It is noteworthy that, in previous studies, this compound was found to be a strong inhibitor of blood-stages of Plasmodium falciparum, thus displaying a dual-stage antimalarial activity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRamalhete, C., Cruz, F. P., Mulhovo, S., Sousa, I. J., Fernandes, M. X., Prudêncio, M., & Ferreira, M. J. U. (2014). Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite. Bioorganic & Medicinal Chemistry, 22(15), 3887-3890.pt_PT
dc.identifier.doi10.1016/j.bmc.2014.06.019pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5028
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUtilization of host cell resources by the malaria parasite in the liver
dc.relationSEARCH FOR ACTIVE COMPOUNDS FROM MEDICINAL PLANTS USED AS ANTIMALARIALS
dc.relationCHEMICAL LIBRARIES SCREENING - SEARCHING FOR NEW ANTI-MALARIAL DRUGS
dc.relationStrategic Project - UI 674 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimalarialspt_PT
dc.subjectMomordica balsaminapt_PT
dc.subjectTriterpenoidspt_PT
dc.subjectDual stagept_PT
dc.subjectPlasmodium bergheipt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleDual-stage triterpenoids from an African medicinal plant targeting the malaria parasitept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUtilization of host cell resources by the malaria parasite in the liver
oaire.awardTitleSEARCH FOR ACTIVE COMPOUNDS FROM MEDICINAL PLANTS USED AS ANTIMALARIALS
oaire.awardTitleCHEMICAL LIBRARIES SCREENING - SEARCHING FOR NEW ANTI-MALARIAL DRUGS
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-MIC%2F117060%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F22321%2F2005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F64539%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.citation.endPage3890pt_PT
oaire.citation.issue15pt_PT
oaire.citation.startPage3887pt_PT
oaire.citation.titleBioorganic & Medicinal Chemistrypt_PT
oaire.citation.volume22pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFernandes
person.givenNameMiguel Xavier
person.identifier.ciencia-idED1D-3C7A-467C
person.identifier.orcid0000-0002-1840-616X
person.identifier.ridA-4373-2013
person.identifier.scopus-author-id35466972500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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