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Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island

2017Journal article Open access
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dc.contributor.authorSousa, Ana Célia
dc.contributor.authorPalma dos Reis, Roberto
dc.contributor.authorPereira, Andreia
dc.contributor.authorBorges, Sofia
dc.contributor.authorFreitas, Ana Isabel
dc.contributor.authorGuerra, Graça
dc.contributor.authorGóis, Teresa
dc.contributor.authorRodrigues, Mariana
dc.contributor.authorHenriques, Eva
dc.contributor.authorFreitas, Sónia
dc.contributor.authorOrnelas, Ilídio
dc.contributor.authorPereira, Décio
dc.contributor.authorBrehm, António
dc.contributor.authorMendonça, Maria Isabel
dc.date.accessioned2020-11-13T14:48:14Z
dc.date.available2020-11-13T14:48:14Z
dc.date.issued2017
dc.description.abstractEssential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population from Madeira Island.A case-control study with 1614 individuals of Caucasian origin was performed, including 817 individuals with EH and 797 controls. Cases and controls were matched for sex and age, by frequency-matching method. All participants collected blood for biochemical and genotypic analysis for the Gly460Trp polymorphism. We further investigated which variables were independently associated to EH, and, consequently, analyzed their interactions.In our study, we found a significant association between the ADD1 gene polymorphism and EH (odds ratio 2.484, P = .01). This association remained statistically significant after the multivariate analysis (odds ratio 2.548, P = .02).The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with EH risk in our population. The knowledge of genetic polymorphisms associated with EH is of paramount importance because it leads to a better understanding of the etiology and pathophysiology of this pathology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSousa, A. C., dos Reis, R. P., Pereira, A., Borges, S., Freitas, A. I., Guerra, G., ... & Ornelas, I. (2017). Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island. Medicine, 96(42).pt_PT
dc.identifier.doi10.1097/MD.0000000000007861pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/2978
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Healthpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectADD1 Gly460Trp gene polymorphismpt_PT
dc.subjectCase-control studypt_PT
dc.subjectEssential hypertensionpt_PT
dc.subjectMadeira Island (Portugal)pt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleRelationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Islandpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagee7861pt_PT
oaire.citation.titleMedicinept_PT
oaire.citation.volume96(42)pt_PT
person.familyNameBrehm
person.givenNameAntonio
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-idAuthor ID 7006085833
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication62d279e2-247a-4652-a370-3e8c2a846e31
relation.isAuthorOfPublication.latestForDiscovery62d279e2-247a-4652-a370-3e8c2a846e31

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