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Volatilomics: an emerging and promising avenue for the detection of potential prostate cancer biomarkers
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Orientador(es)
Resumo(s)
Despite the spectacular advances in molecular medicine, including genomics, proteomics,
transcriptomics, lipidomics, and personalized medicine, supported by the discovery of the human
genome, prostate cancer (PCa) remains the most frequent malignant tumor and a leading cause
of oncological death in men. New methods for prognostic, diagnostic, and therapy evaluation are
mainly based on the combination of imaging techniques with other methodologies, such as gene or
protein profiling, aimed at improving PCa management and surveillance. However, the lack of highly
specific and sensitive biomarkers for its early detection is a major hurdle to this goal. Apart from
classical biomarkers, the study of endogenous volatile organic metabolites (VOMs) biosynthesized by
different metabolic pathways and found in several biofluids is emerging as an innovative, efficient,
accessible, and non-invasive approach to establish the volatilomic biosignature of PCa patients,
unravelling potential biomarkers. This review provides a brief overview of the challenges of PCa
screening methods and emergent biomarkers. We also focus on the potential of volatilomics for the
establishment of PCa biomarkers from non-invasive matrices.
Descrição
Palavras-chave
Prostate cancer Diagnosis Volatilomics Tumor biomarkers . Centro de Química da Madeira Faculdade de Ciências Exatas e da Engenharia
Contexto Educativo
Citação
Berenguer, C.V.; Pereira, F.; Pereira, J.A.M.; Câmara, J.S. Volatilomics: An Emerging and Promising Avenue for the Detection of Potential Prostate Cancer Biomarkers. Cancers 2022, 14, 3982. https://doi.org/10.3390/ cancers14163982
Editora
MDPI