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Volatilomics: an emerging and promising avenue for the detection of potential prostate cancer biomarkers

2022Journal article Open access
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dc.contributor.authorBerenguer, Cristina V.
dc.contributor.authorPereira, Ferdinando
dc.contributor.authorPereira, Jorge A. M.
dc.contributor.authorCamara, José S.
dc.date.accessioned2024-07-16T10:12:56Z
dc.date.available2024-07-16T10:12:56Z
dc.date.issued2022
dc.description.abstractDespite the spectacular advances in molecular medicine, including genomics, proteomics, transcriptomics, lipidomics, and personalized medicine, supported by the discovery of the human genome, prostate cancer (PCa) remains the most frequent malignant tumor and a leading cause of oncological death in men. New methods for prognostic, diagnostic, and therapy evaluation are mainly based on the combination of imaging techniques with other methodologies, such as gene or protein profiling, aimed at improving PCa management and surveillance. However, the lack of highly specific and sensitive biomarkers for its early detection is a major hurdle to this goal. Apart from classical biomarkers, the study of endogenous volatile organic metabolites (VOMs) biosynthesized by different metabolic pathways and found in several biofluids is emerging as an innovative, efficient, accessible, and non-invasive approach to establish the volatilomic biosignature of PCa patients, unravelling potential biomarkers. This review provides a brief overview of the challenges of PCa screening methods and emergent biomarkers. We also focus on the potential of volatilomics for the establishment of PCa biomarkers from non-invasive matrices.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBerenguer, C.V.; Pereira, F.; Pereira, J.A.M.; Câmara, J.S. Volatilomics: An Emerging and Promising Avenue for the Detection of Potential Prostate Cancer Biomarkers. Cancers 2022, 14, 3982. https://doi.org/10.3390/ cancers14163982pt_PT
dc.identifier.doi10.3390/cancers14163982pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5748
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectProstate cancerpt_PT
dc.subjectDiagnosispt_PT
dc.subjectVolatilomicspt_PT
dc.subjectTumor biomarkerspt_PT
dc.subject.pt_PT
dc.subjectCentro de Química da Madeirapt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleVolatilomics: an emerging and promising avenue for the detection of potential prostate cancer biomarkerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.issue16pt_PT
oaire.citation.startPage3982pt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBerenguer
person.familyNameAugusto Machado Pereira
person.familyNameCâmara
person.givenNameCristina
person.givenNameJorge
person.givenNameJosé
person.identifierG-3003-2013
person.identifier.ciencia-idA813-68FE-C3C3
person.identifier.ciencia-idEC12-EE8F-50E8
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.orcid0000-0002-1762-1175
person.identifier.orcid0000-0003-0316-5348
person.identifier.orcid0000-0003-1965-3151
person.identifier.scopus-author-id10140393000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicatione10d78be-e547-4d25-92b5-06a997ed78da
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