Loading...
Publication
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.86 MB | Adobe PDF |
Advisor(s)
Abstract(s)
Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used
to diagnose diabetes, but these measurements can identify diferent
people as having diabetes. We used data from 117 population-based studies
and quantifed, in diferent world regions, the prevalence of diagnosed
diabetes, and whether those who were previously undiagnosed and
detected as having diabetes in survey screening, had elevated FPG, HbA1c
or both. We developed prediction equations for estimating the probability
that a person without previously diagnosed diabetes, and at a specifc
level of FPG, had elevated HbA1c, and vice versa. The age-standardized
proportion of diabetes that was previously undiagnosed and detected in
survey screening ranged from 30% in the high-income western region to
66% in south Asia. Among those with screen-detected diabetes with either
test, the age-standardized proportion who had elevated levels of both
FPG and HbA1c was 29–39% across regions; the remainder had discordant
elevation of FPG or HbA1c. In most low- and middle-income regions,
isolated elevated HbA1c was more common than isolated elevated FPG.
In these regions, the use of FPG alone may delay diabetes diagnosis and
underestimate diabetes prevalence. Our prediction equations help allocate
fnite resources for measuring HbA1c to reduce the global shortfall in
diabetes diagnosis and surveillance.
Description
Keywords
Diabetes Diagnosis Diagnostic markers Epidemiology Public health . Faculdade de Ciências Sociais
Citation
NCD Risk Factor Collaboration (NCD-RisC). Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c. Nat Med 29, 2885–2901 (2023). https://doi.org/10.1038/s41591-023-02610-2
Publisher
Nature Research