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Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

2023Journal article Open access
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dc.contributor.authorNCD Risk Factor Collaboration (NCD-RisC)
dc.contributor.authorOrnelas, Rui
dc.date.accessioned2024-05-23T11:11:05Z
dc.date.available2024-05-23T11:11:05Z
dc.date.issued2023
dc.description.abstractFasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify diferent people as having diabetes. We used data from 117 population-based studies and quantifed, in diferent world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specifc level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate fnite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNCD Risk Factor Collaboration (NCD-RisC). Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c. Nat Med 29, 2885–2901 (2023). https://doi.org/10.1038/s41591-023-02610-2pt_PT
dc.identifier.doi10.1038/s41591-023-02610-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5700
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDiabetespt_PT
dc.subjectDiagnosispt_PT
dc.subjectDiagnostic markerspt_PT
dc.subjectEpidemiologypt_PT
dc.subjectPublic healthpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Sociaispt_PT
dc.titleGlobal variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1cpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2901pt_PT
oaire.citation.startPage2885pt_PT
oaire.citation.titleNature medicinept_PT
oaire.citation.volume29pt_PT
person.familyNameOrnelas
person.givenNameRui
person.identifier.ciencia-idA71A-D19E-55F4
person.identifier.orcid0000-0003-3737-7402
person.identifier.scopus-author-id24335790700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication05370ce4-254d-4ca7-a937-9036407655c2
relation.isAuthorOfPublication.latestForDiscovery05370ce4-254d-4ca7-a937-9036407655c2

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