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A deficiência de vitamina D como fator de risco para a doença cardiovascular
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Abstract(s)
A deficiência de vitamina D, reconhecida como “a vitamina do sol”, constitui um fator de risco para o desenvolvimento de raquitismo, osteomalacia e osteoporose. Contudo, parece também existir uma relação entre a deficiência de vitamina D e outras doenças crónicas. O principal objetivo deste trabalho foi avaliar a relação entre a deficiência de vitamina D e as doenças cardiovasculares e, simultaneamente, fazer uma avaliação preliminar da deficiência de vitamina D na população madeirense. Assim, determinou-se a concentração sérica de 25(OH)D de 100 indivíduos saudáveis e 94 indivíduos com doença cardiovascular. A todos avaliou-se o perfil lipídico, o valor de HA1C e as concentrações séricas de glicose, insulina, fibrinogénio, PCRhs e homocisteína. Recolheram-se, ainda, dados antropométricos e informações acerca do estilo de vida. Obteve-se uma diferença significativa na concentração sérica de 25(OH)D entre controlos saudáveis e doentes cardiovasculares e constatou-se que as mulheres tinham uma concentração sérica de 25(OH)D mais baixa que os homens. Verificou-se que os indivíduos com níveis suficientes de vitamina D apresentavam um perfil lipídico e concentrações de APO B, glicose, insulina e valores de HA1C mais favoráveis. Curiosamente, a concentração sérica de PCRhs e de fibrinogénio era menor nos indivíduos com insuficiência de vitamina D, notando-se a mesma tendência na concentração de homocisteína dos doentes cardiovasculares. Também se verificou que a concentração de Lp(a) era maior nos indivíduos com níveis suficientes de vitamina D. Constatou-se, ainda, que havia uma relação inversa entre o estado de vitamina D e a altura dos indivíduos. Por último, apesar da Madeira estar numa posição geográfica favorável à produção de vitamina D durante todo o ano, verificou-se que a deficiência e insuficiência de vitamina D são frequentes. Porém, importa salientar que este foi um estudo preliminar nesse sentido e, para uma melhor avaliação, seria necessária uma amostra mais representativa da população madeirense.
Deficiency of vitamin D, known as "vitamin of the sun", is a risk factor for the development of rickets, osteomalacia and osteoporosis. However, it seems that vitamin D deficiency is also related to other chronic diseases. The aim of this study was to evaluate the relationship between vitamin D deficiency and cardiovascular disease and, additionally, to accomplish a preliminary assessment of vitamin D deficiency in Madeira population. For this purpose, serum 25(OH)D was determined in 100 healthy subjects and 94 individuals with cardiovascular disease. Also, the lipid profile, HA1C values and serum concentrations of glucose, insulin, fibrinogen, PCRhs and homocysteine were evaluated. Moreover, the anthropometric data and lifestyle information were obtained. A significant difference in serum 25(OH)D was observed between healthy controls and cardiovascular patients and it was found that serum 25(OH)D was lower in women than in men. Individuals with adequate levels of vitamin D had better lipid profiles and lower APO B, glucose, insulin and HA1C values. Interestingly, serum PCRhs and fibrinogen were lower in vitamin D insufficient individuals and the same trend was observed for homocysteine concentrations in cardiovascular disease patients. Also, Lp(a) concentrations were higher in individuals with sufficient levels of vitamin D. Additionally, an inverse relationship between vitamin D status and height was observed for the whole sample. Finally, despite Madeira favorable geographic location for the production of vitamin D all over the year, vitamin D deficiency or insufficiency are frequent. However, this was a preliminary study and, for a better evaluation, a representative sample of Madeira population would be required.
Deficiency of vitamin D, known as "vitamin of the sun", is a risk factor for the development of rickets, osteomalacia and osteoporosis. However, it seems that vitamin D deficiency is also related to other chronic diseases. The aim of this study was to evaluate the relationship between vitamin D deficiency and cardiovascular disease and, additionally, to accomplish a preliminary assessment of vitamin D deficiency in Madeira population. For this purpose, serum 25(OH)D was determined in 100 healthy subjects and 94 individuals with cardiovascular disease. Also, the lipid profile, HA1C values and serum concentrations of glucose, insulin, fibrinogen, PCRhs and homocysteine were evaluated. Moreover, the anthropometric data and lifestyle information were obtained. A significant difference in serum 25(OH)D was observed between healthy controls and cardiovascular patients and it was found that serum 25(OH)D was lower in women than in men. Individuals with adequate levels of vitamin D had better lipid profiles and lower APO B, glucose, insulin and HA1C values. Interestingly, serum PCRhs and fibrinogen were lower in vitamin D insufficient individuals and the same trend was observed for homocysteine concentrations in cardiovascular disease patients. Also, Lp(a) concentrations were higher in individuals with sufficient levels of vitamin D. Additionally, an inverse relationship between vitamin D status and height was observed for the whole sample. Finally, despite Madeira favorable geographic location for the production of vitamin D all over the year, vitamin D deficiency or insufficiency are frequent. However, this was a preliminary study and, for a better evaluation, a representative sample of Madeira population would be required.
Description
Keywords
Vitamina D 25-hidroxivitamina D 1,25-dihidroxivitamina D 1α-hidroxilase Doença cardiovascular Vitamin D 25-hidroxyvitamin D 1,25-dihidroxyvitamin D 1α-hidroxylase Cardiovascular disease Bioquímica Aplicada . Faculdade de Ciências da Vida