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A small molecule tubulin depolymerizing agent identified by a phenotypic drug discovery approach

2018Journal article Open access
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dc.contributor.authorRíos-Luci, Carla
dc.contributor.authorDíaz-Rodríguez, Elena
dc.contributor.authorBuey, Ruben M.
dc.contributor.authorSousa, Inês J.
dc.contributor.authorFernandes, Miguel X.
dc.contributor.authorPandiella, Atanasio
dc.contributor.authorPadrón, José M.
dc.date.accessioned2023-02-13T14:06:20Z
dc.date.available2023-02-13T14:06:20Z
dc.date.issued2018
dc.description.abstractIn the scenario of drug discovery, numerous in vitro testing initiatives had been established. Thus far, no general methodology is reputable and literature on this hot topic is scarce. In this respect, we propose a strategy based on a Phenotypic Drug Discovery approach. Within our program directed at the discovery of new antitumor agents, we have focused our attention on compounds that disturb the cell cycle. Our strategy relies on the use of a set of biological assays organized in a modular fashion. Herein, we exemplified this strategy with a family of propargylic enol ether derivatives. Using different assays in sequential stages and in a stepwise manner, our studies allowed us to understand the bioactivity of this family of compounds and led us to identify tubulin as the main molecular target.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRíos-Luci, C., Díaz-Rodríguez, E., Buey, R. M., Sousa, I. J., Fernandes, M. X., Pandiella, A., & Padrón, J. M. (2018). A small molecule tubulin depolymerizing agent identified by a phenotypic drug discovery approach. Journal of Molecular and Clinical Medicine, 1(2), 67-76.pt_PT
dc.identifier.doi10.31083/j.jmcm.2018.02.003pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5031
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIMR Presspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnti-cancerpt_PT
dc.subjectColchicine binding sitept_PT
dc.subjectDrug-target interactionpt_PT
dc.subjectMicrotubule-targeting agentspt_PT
dc.subjectTubulin-depolymerizing agentspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleA small molecule tubulin depolymerizing agent identified by a phenotypic drug discovery approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage76pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage67pt_PT
oaire.citation.titleJournal of Molecular and Clinical Medicinept_PT
oaire.citation.volume1pt_PT
person.familyNameFernandes
person.givenNameMiguel Xavier
person.identifier.ciencia-idED1D-3C7A-467C
person.identifier.orcid0000-0002-1840-616X
person.identifier.ridA-4373-2013
person.identifier.scopus-author-id35466972500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8dab9a0d-f44a-4d2d-b9b1-7b3145162ca3
relation.isAuthorOfPublication.latestForDiscovery8dab9a0d-f44a-4d2d-b9b1-7b3145162ca3

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