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Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells

2018Journal article Open access
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dc.contributor.authorGouveia, Marisol
dc.contributor.authorFigueira, João
dc.contributor.authorJardim, Manuel G.
dc.contributor.authorCastro, Rita
dc.contributor.authorTomás, Helena
dc.contributor.authorRissanen, Kari
dc.contributor.authorRodrigues, João
dc.date.accessioned2018-07-31T09:26:16Z
dc.date.available2018-07-31T09:26:16Z
dc.date.issued2018
dc.description.abstractHere and for the first time, we show that the organometallic compound [Ru(η5-C5H5)(PPh3)2Cl] (RuCp) has potential to be used as a metallodrug in anticancer therapy, and further present a new approach for the cellular delivery of the [Ru(η5-C5H5)(PPh3)2]+ fragment via coordination on the periphery of low-generation poly(alkylidenimine) dendrimers through nitrile terminal groups. Importantly, both the RuCp and the dendrimers functionalized with [Ru(η5-C5H5)(PPh3)2]+ fragments present remarkable toxicity towards a wide set of cancer cells (Caco-2, MCF-7, CAL-72, and A2780 cells), including cisplatin-resistant human ovarian carcinoma celllines(A2780cisRcells). Also,RuCpandthepreparedmetallodendrimersareactiveagainsthuman mesenchymal stem cells (hMSCs), which are often found in the tumor microenvironment where they seem to play a role in tumor progression and drug resistance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGouveia, M.; Figueira, J.; Jardim, M.G.; Castro, R.; Tomás, H.; Rissanen, K.; Rodrigues, J. Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells. Molecules 2018, 23, 1471.pt_PT
dc.identifier.doi10.3390/molecules23061471pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.13/2069
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDendrimerspt_PT
dc.subjectNanocarrierspt_PT
dc.subjectMetallodrugspt_PT
dc.subjectRutheniumpt_PT
dc.subjectPlatinumpt_PT
dc.subjectCisplatinpt_PT
dc.subjectCancer treatmentpt_PT
dc.subjecthMSCspt_PT
dc.subjectToxicitypt_PT
dc.subjectNanomedicinept_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titlePoly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.endPage17pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume23, 1471pt_PT
person.familyNameGouveia
person.familyNameFigueira
person.familyNameCastro
person.familyNameTomás
person.familyNameRissanen
person.familyNameRodrigues
person.givenNameMarisol
person.givenNameJoão
person.givenNameRita
person.givenNameHelena
person.givenNameKari
person.givenNameJoão
person.identifier556975
person.identifier.ciencia-id8314-881E-4986
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.orcid0000-0002-6489-5283
person.identifier.orcid0000-0001-8819-2278
person.identifier.orcid0000-0002-9337-062X
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0002-7282-8419
person.identifier.orcid0000-0003-4552-1953
person.identifier.ridA-3631-2013
person.identifier.ridA-2497-2013
person.identifier.ridE-5991-2010
person.identifier.ridB-6816-2008
person.identifier.scopus-author-id53864978400
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id9233278800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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