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Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review

2022Journal article Open access
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dc.contributor.authorSun, Huxiao
dc.contributor.authorZhan, Mengsi
dc.contributor.authorMignani, Serge
dc.contributor.authorShcharbin, Dzmitry
dc.contributor.authorMajoral, Jean-Pierre
dc.contributor.authorRodrigues, João
dc.contributor.authorShi, Xiangyang
dc.contributor.authorShen, Mingwu
dc.date.accessioned2024-03-01T14:46:24Z
dc.date.available2024-03-01T14:46:24Z
dc.date.issued2022
dc.description.abstractCurcumin (Cur), a traditional Chinese medicine extracted from natural plant rhizomes, has become a candidate drug for the treatment of diseases due to its anti-inflammatory, anticancer, antioxidant, and antibacterial activities. However, the poor water solubility and low bioavailability of Cur limit its therapeutic effects for clinical applications. A variety of nanocarriers have been successfully developed to improve the water solubility, in vivo distribution, and pharmacokinetics of Cur, as well as to enhance the ability of Cur to polarize macrophages and relieve macrophage oxidative stress or anti-apoptosis, thus accelerating the therapeutic effects of Cur on inflammatory diseases. Herein, we review the design and development of diverse Cur nanoformulations in recent years and introduce the biomedical applications and potential therapeutic mechanisms of Cur nanoformulations in common inflammatory diseases, such as arthritis, neurodegenerative diseases, respiratory diseases, and ulcerative colitis, by regulating macrophage behaviors. Finally, the perspectives of the design and preparation of future nanocarriers aimed at efficiently exerting the biological activity of Cur are briefly discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSun, H.; Zhan, M.; Mignani, S.; Shcharbin, D.; Majoral, J.-P.; Rodrigues, J.; Shi, X.; Shen, M. Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review. Pharmaceutics 2022, 14, 2239. https://doi.org/10.3390/ pharmaceutics14102239pt_PT
dc.identifier.doi10.3390/pharmaceutics14102239pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5597
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCurcuminpt_PT
dc.subjectNanoformulationspt_PT
dc.subjectBioavailabilitypt_PT
dc.subjectDrug deliverypt_PT
dc.subjectInflammationpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleModulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.startPage2239pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume14pt_PT
person.familyNameMignani
person.familyNameShcharbin
person.familyNameRodrigues
person.familyNameShi
person.familyNameShen
person.givenNameSerge
person.givenNameDzmitry
person.givenNameJoão
person.givenNameXiangyang
person.givenNameMingwu
person.identifier478951
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-idBA11-1437-B948
person.identifier.orcid0000-0002-1383-5256
person.identifier.orcid0000-0002-1414-4465
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0001-6785-6645
person.identifier.orcid0000-0002-1065-0854
person.identifier.ridG-2046-2011
person.identifier.ridB-6816-2008
person.identifier.ridA-1289-2007
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id14011784800
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id7402953116
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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