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Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review
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| 10.74 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Curcumin (Cur), a traditional Chinese medicine extracted from natural plant rhizomes,
has become a candidate drug for the treatment of diseases due to its anti-inflammatory, anticancer,
antioxidant, and antibacterial activities. However, the poor water solubility and low bioavailability
of Cur limit its therapeutic effects for clinical applications. A variety of nanocarriers have been
successfully developed to improve the water solubility, in vivo distribution, and pharmacokinetics of
Cur, as well as to enhance the ability of Cur to polarize macrophages and relieve macrophage oxidative
stress or anti-apoptosis, thus accelerating the therapeutic effects of Cur on inflammatory diseases.
Herein, we review the design and development of diverse Cur nanoformulations in recent years and
introduce the biomedical applications and potential therapeutic mechanisms of Cur nanoformulations
in common inflammatory diseases, such as arthritis, neurodegenerative diseases, respiratory diseases,
and ulcerative colitis, by regulating macrophage behaviors. Finally, the perspectives of the design
and preparation of future nanocarriers aimed at efficiently exerting the biological activity of Cur are
briefly discussed.
Descrição
Palavras-chave
Curcumin Nanoformulations Bioavailability Drug delivery Inflammation . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Contexto Educativo
Citação
Sun, H.; Zhan, M.; Mignani, S.; Shcharbin, D.; Majoral, J.-P.; Rodrigues, J.; Shi, X.; Shen, M. Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review. Pharmaceutics 2022, 14, 2239. https://doi.org/10.3390/ pharmaceutics14102239
Editora
MDPI