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Publication
Atypical functional connectivity during unfamiliar music listening in children with autism
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Advisor(s)
Abstract(s)
Background: Atypical processing of unfamiliar, but less so familiar, stimuli has been
described in Autism Spectrum Disorder (ASD), in particular in relation to face processing.
We examined the construct of familiarity in ASD using familiar and unfamiliar songs,
to investigate the link between familiarity and autism symptoms, such as repetitive
behavior.
Methods: Forty-eight children, 24 with ASD (21 males, mean age = 9.96 years ± 1.54)
and 24 typically developing (TD) controls (21 males, mean age = 10.17 ± 1.90)
completed a music familiarity task using individually identified familiar compared to
unfamiliar songs, while magnetoencephalography (MEG) was recorded. Each song
was presented for 30 s. We used both amplitude envelope correlation (AEC) and the
weighted phase lag index (wPLI) to assess functional connectivity between specific
regions of interest (ROI) and non-ROI parcels, as well as at the whole brain level,
to understand what is preserved and what is impaired in familiar music listening in
this population.
Results: Increased wPLI synchronization for familiar vs. unfamiliar music was found
for typically developing children in the gamma frequency. There were no significant
differences within the ASD group for this comparison. During the processing of unfamiliar
music, we demonstrated left lateralized increased theta and beta band connectivity in
children with ASD compared to controls. An interaction effect found greater alpha band
connectivity in the TD group compared to ASD to unfamiliar music only, anchored in
the left insula.Conclusion: Our results revealed atypical processing of unfamiliar songs in children
with ASD, consistent with previous studies in other modalities reporting that processing
novelty is a challenge for ASD. Relatively typical processing of familiar stimuli may
represent a strength and may be of interest to strength-based intervention planning.
Description
Keywords
Autism spectrum disorder Music Familiarity processing Magnetoencephalography Neural oscillation Functional connectivity . Faculdade de Ciências da Vida
Citation
Freitas, C., Hunt, B. A., Wong, S. M., Ristic, L., Fragiadakis, S., Chow, S., ... & Anagnostou, E. (2022). Atypical functional connectivity during unfamiliar music listening in children with autism. Frontiers in neuroscience, 16. doi: 10.3389/fnins.2022.829415
Publisher
Frontiers Media