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Atypical functional connectivity during unfamiliar music listening in children with autism

2022Journal article Open access
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dc.contributor.authorFreitas, Carina
dc.contributor.authorHunt, Benjamin A. E.
dc.contributor.authorWong, Simeon M.
dc.contributor.authorRistic, Leanne
dc.contributor.authorFragiadakis, Susan
dc.contributor.authorChow, Stephanie
dc.contributor.authorIaboni, Alana
dc.contributor.authorBrian, Jessica
dc.contributor.authorSoorya, Latha
dc.contributor.authorChen, Joyce L.
dc.contributor.authorSchachar, Russell
dc.contributor.authorDunkley, Benjamin T.
dc.contributor.authorTaylor, Margot J.
dc.contributor.authorLerch, Jason P.
dc.contributor.authorAnagnostou, Evdokia
dc.date.accessioned2022-06-09T09:19:59Z
dc.date.available2022-06-09T09:19:59Z
dc.date.issued2022
dc.description.abstractBackground: Atypical processing of unfamiliar, but less so familiar, stimuli has been described in Autism Spectrum Disorder (ASD), in particular in relation to face processing. We examined the construct of familiarity in ASD using familiar and unfamiliar songs, to investigate the link between familiarity and autism symptoms, such as repetitive behavior. Methods: Forty-eight children, 24 with ASD (21 males, mean age = 9.96 years ± 1.54) and 24 typically developing (TD) controls (21 males, mean age = 10.17 ± 1.90) completed a music familiarity task using individually identified familiar compared to unfamiliar songs, while magnetoencephalography (MEG) was recorded. Each song was presented for 30 s. We used both amplitude envelope correlation (AEC) and the weighted phase lag index (wPLI) to assess functional connectivity between specific regions of interest (ROI) and non-ROI parcels, as well as at the whole brain level, to understand what is preserved and what is impaired in familiar music listening in this population. Results: Increased wPLI synchronization for familiar vs. unfamiliar music was found for typically developing children in the gamma frequency. There were no significant differences within the ASD group for this comparison. During the processing of unfamiliar music, we demonstrated left lateralized increased theta and beta band connectivity in children with ASD compared to controls. An interaction effect found greater alpha band connectivity in the TD group compared to ASD to unfamiliar music only, anchored in the left insula.Conclusion: Our results revealed atypical processing of unfamiliar songs in children with ASD, consistent with previous studies in other modalities reporting that processing novelty is a challenge for ASD. Relatively typical processing of familiar stimuli may represent a strength and may be of interest to strength-based intervention planning.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFreitas, C., Hunt, B. A., Wong, S. M., Ristic, L., Fragiadakis, S., Chow, S., ... & Anagnostou, E. (2022). Atypical functional connectivity during unfamiliar music listening in children with autism. Frontiers in neuroscience, 16. doi: 10.3389/fnins.2022.829415pt_PT
dc.identifier.doi10.3389/fnins.2022.829415pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4319
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationNeuroimaging studies on familiarity and likeability of music in children with autism spectrum disorder
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAutism spectrum disorderpt_PT
dc.subjectMusicpt_PT
dc.subjectFamiliarity processingpt_PT
dc.subjectMagnetoencephalographypt_PT
dc.subjectNeural oscillationpt_PT
dc.subjectFunctional connectivitypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleAtypical functional connectivity during unfamiliar music listening in children with autismpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNeuroimaging studies on familiarity and likeability of music in children with autism spectrum disorder
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F116213%2F2016/PT
oaire.citation.titleFrontiers in Neurosciencept_PT
oaire.citation.volume16pt_PT
person.familyNameDe Barros Freitas
person.givenNameCarina Patrícia
person.identifier.ciencia-id1616-9C71-0359
person.identifier.orcid0000-0002-3713-9386
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery2caaa44a-cb70-4016-ade0-2426574e24df
relation.isProjectOfPublication257ed3e4-0d37-4773-ab0b-e0c4a9014113
relation.isProjectOfPublication.latestForDiscovery257ed3e4-0d37-4773-ab0b-e0c4a9014113

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