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Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise review

2020Journal article Open access
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dc.contributor.authorSong, Cong
dc.contributor.authorShen, Mingwu
dc.contributor.authorRodrigues, João
dc.contributor.authorMignani, Serge
dc.contributor.authorMajoral, Jean-Pierre
dc.contributor.authorShi, Xiangyang
dc.date.accessioned2022-02-21T11:21:43Z
dc.date.available2022-02-21T11:21:43Z
dc.date.issued2020
dc.description.abstractPoly(amidoamine) (PAMAM) dendrimers, as a family of synthetic macromolecules with highly branched interiors, abundant surface functional groups, and well-controlled architecture, have received immense scientific and technological interests for a range of biomedical applications, in particular cancer nanome dicine. However, due to the drawbacks of single-generation dendrimers with a quite small size (e.g., gen eration 5 (G5) PAMAM dendrimer has a size of 5.4 nm) such as limited drug loading capacity, restricted tumor passive targeting based on enhanced permeability and retention effect, and lack of versatility to render them with stimuli-responsiveness, superstructured dendrimeric nanoconstructs (SDNs) have been designed to break through these obstacles in their applications in cancer nanomedicine. Here, we review the recent advances related to the creation of SDNs such as dendrimer dumbbells, core–shell tecto den drimers, dendrimer nanoclusters (NCs), dendrimer nanogels and dendrimer-templated hybrid NCs, and how these SDNs have been designed as nanoplatforms for different biomedical applications related to cancer nanomedicine including MR imaging, drug/gene delivery, combination therapy and theranostics. This review concisely describes the latest key developments in the field and also discusses the possible challenges and perspectives for translation applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSong, C., Shen, M., Rodrigues, J., Mignani, S., Majoral, J. P., & Shi, X. (2020). Superstructured poly (amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise review. Coordination Chemistry Reviews, 421, 213463. https://doi.org/10.1016/j.ccr.2020.213463pt_PT
dc.identifier.doi10.1016/j.ccr.2020.213463pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4097
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDendrimerspt_PT
dc.subjectSuperstructurespt_PT
dc.subjectSynthesispt_PT
dc.subjectSelf-assemblypt_PT
dc.subjectCancer nanomedicinpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleSuperstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.startPage213463pt_PT
oaire.citation.titleCoordination Chemistry Reviewspt_PT
oaire.citation.volume421pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRodrigues
person.familyNameMignani
person.familyNameShi
person.givenNameJoão
person.givenNameSerge
person.givenNameXiangyang
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.ciencia-idBA11-1437-B948
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-1383-5256
person.identifier.orcid0000-0001-6785-6645
person.identifier.ridB-6816-2008
person.identifier.ridA-1289-2007
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id7402953116
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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