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Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise review
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Advisor(s)
Abstract(s)
Poly(amidoamine) (PAMAM) dendrimers, as a family of synthetic macromolecules with highly branched
interiors, abundant surface functional groups, and well-controlled architecture, have received immense
scientific and technological interests for a range of biomedical applications, in particular cancer nanome dicine. However, due to the drawbacks of single-generation dendrimers with a quite small size (e.g., gen eration 5 (G5) PAMAM dendrimer has a size of 5.4 nm) such as limited drug loading capacity, restricted
tumor passive targeting based on enhanced permeability and retention effect, and lack of versatility to
render them with stimuli-responsiveness, superstructured dendrimeric nanoconstructs (SDNs) have been
designed to break through these obstacles in their applications in cancer nanomedicine. Here, we review
the recent advances related to the creation of SDNs such as dendrimer dumbbells, core–shell tecto den drimers, dendrimer nanoclusters (NCs), dendrimer nanogels and dendrimer-templated hybrid NCs, and
how these SDNs have been designed as nanoplatforms for different biomedical applications related to
cancer nanomedicine including MR imaging, drug/gene delivery, combination therapy and theranostics.
This review concisely describes the latest key developments in the field and also discusses the possible
challenges and perspectives for translation applications.
Description
Keywords
Dendrimers Superstructures Synthesis Self-assembly Cancer nanomedicin . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Citation
Song, C., Shen, M., Rodrigues, J., Mignani, S., Majoral, J. P., & Shi, X. (2020). Superstructured poly (amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise review. Coordination Chemistry Reviews, 421, 213463. https://doi.org/10.1016/j.ccr.2020.213463
Publisher
Elsevier