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In vitro studies on the effect of watercress juice on digestive enzymes relevant to type 2 diabetes and obesity and antioxidant activity

2017Journal article Open access
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dc.contributor.authorSpínola, Vítor
dc.contributor.authorPinto, Joana
dc.contributor.authorCastilho, Paula C.
dc.date.accessioned2021-03-29T10:47:55Z
dc.date.available2021-03-29T10:47:55Z
dc.date.issued2017
dc.description.abstractInhibition of enzymes involved in carbohydrate and lipids metabolism is an important strategy against type 2 diabetes and obesity, by suppressing dietary sugar and fat absorption. This work reports, for the first time, the in vitro inhibition of a-glucosidase, a-amylase and lipase by water cress juice (WJ). Juice was analyzed for qualitative and quantitative composition and in vitro antioxidant activities. Several components were identified, namely hydroxycinnamic acids, flavo nols, and other minor water-soluble phytochemicals. Quantitative data revealed a dimer of caffeoylmalic acid (0.73 mg mL21 of juice), disinapoylgentibiose (0.64 mg mL21 ), ferulic acid (0.56 mg mL21 ), and isorhamnetin-O-sophoroside-O-malonyl(hexoside) (0.38 mg mL21 ) as the pre dominant polyphenols. The results showed that WJ had dose-dependent inhibitory potential against targeted enzymes, displaying a more potent inhibitory effect against a-glucosidase relative to a-amylase and lipase. WJ can be considered a potential complementary dietary approach to control hyperglycaemia and hyperlipidaemia, through inhibition of digestive enzymes. Practical applications Currently, raw watercress is widely consumed in liquid form, alone or together with other fresh vege tables, as an ingredient of the “detox juices.” Studies on watercress phenolic composition and antidiabetic properties have been performed on extracts, but not on juice, which is closer to the edi ble form. The present study supports consumption of watercress juice as source of phytochemicals potentially capable of inhibiting digestive enzymes linked to diabetes and obesity prevention/control.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, V., Pinto, J., & Castilho, P. C. (2017). In vitro studies on the effect of watercress juice on digestive enzymes relevant to type 2 diabetes and obesity and antioxidant activity. Journal of Food Biochemistry, 41(1), e12335.pt_PT
dc.identifier.doi10.1111/jfbc.12335pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3213
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectDigestive enzymes inhibitionpt_PT
dc.subjectHyperglycaemiapt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectWatercresspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleIn vitro studies on the effect of watercress juice on digestive enzymes relevant to type 2 diabetes and obesity and antioxidant activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F84672%2F2012/PT
oaire.citation.issue1pt_PT
oaire.citation.startPagee12335pt_PT
oaire.citation.titleJournal of Food Biochemistrypt_PT
oaire.citation.volume41pt_PT
oaire.fundingStreamSFRH
person.familyNameSpínola
person.familyNameNunes Pinto
person.familyNameCastilho
person.givenNameVítor
person.givenNameJoana Carolina
person.givenNamePaula C
person.identifierA-4412-2013
person.identifier.ciencia-id0412-6D53-3A09
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0003-2456-8613
person.identifier.orcid0000-0002-8303-4286
person.identifier.scopus-author-id54881258000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication9f82af5c-7427-4e62-80ac-4c4feb2f615a
relation.isAuthorOfPublicationd84fd917-438e-43bf-ac6f-256562481c05
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relation.isProjectOfPublication34751b34-607a-473a-bc2e-ffc6b725cf18
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