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Publication
Release of adsorbed ferulic acid in simulated gastrointestinal conditions
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Advisor(s)
Abstract(s)
Ferulic acid (FA) is a natural antioxidant with limited absorption when conjugated with biomolecules but whose free form
is readily absorbed in the stomach and, to a lesser extent, in the ileum. The latter sufers from infammation and oxidative
stress, so a novel strategy for the delivery of FA in this compartment of the gastrointestinal tract was developed. Using the
neutral un-functionalized resin Lewatit® VP OC 1064 MD PH, under optimized conditions, a loading of 144 mg FA/g of
dry resin was obtained. By means of an in vitro simulated digestion, an average release of 32 mg FA/g of dry loaded resin
(recovery of 22%) was observed in intestinal conditions. The incorporation/release of FA onto/from the resin was confrmed
by ATR-FTIR spectroscopy and by HPLC-DAD. This work showed that the free form of FA can efectively be delivered in
the small intestine, after immobilization in solid matrices.
Description
Keywords
Ferulic acid Adsorption Release In vitro digestion simulation Intestine . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Citation
Martins, G. N., Spínola, V., & Castilho, P. C. (2020). Release of adsorbed ferulic acid in simulated gastrointestinal conditions. European Food Research and Technology, 246(6), 1297-1306. https://doi.org/10.1007/s00217-020-03489-w
Publisher
Springer