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Release of adsorbed ferulic acid in simulated gastrointestinal conditions
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Orientador(es)
Resumo(s)
Ferulic acid (FA) is a natural antioxidant with limited absorption when conjugated with biomolecules but whose free form
is readily absorbed in the stomach and, to a lesser extent, in the ileum. The latter sufers from infammation and oxidative
stress, so a novel strategy for the delivery of FA in this compartment of the gastrointestinal tract was developed. Using the
neutral un-functionalized resin Lewatit® VP OC 1064 MD PH, under optimized conditions, a loading of 144 mg FA/g of
dry resin was obtained. By means of an in vitro simulated digestion, an average release of 32 mg FA/g of dry loaded resin
(recovery of 22%) was observed in intestinal conditions. The incorporation/release of FA onto/from the resin was confrmed
by ATR-FTIR spectroscopy and by HPLC-DAD. This work showed that the free form of FA can efectively be delivered in
the small intestine, after immobilization in solid matrices.
Descrição
Palavras-chave
Ferulic acid Adsorption Release In vitro digestion simulation Intestine . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira
Contexto Educativo
Citação
Martins, G. N., Spínola, V., & Castilho, P. C. (2020). Release of adsorbed ferulic acid in simulated gastrointestinal conditions. European Food Research and Technology, 246(6), 1297-1306. https://doi.org/10.1007/s00217-020-03489-w
Editora
Springer