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Release of adsorbed ferulic acid in simulated gastrointestinal conditions

2020Journal article Open access
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dc.contributor.authorMartins, Gonçalo N.
dc.contributor.authorSpínola, Vítor
dc.contributor.authorCastilho, Paula C.
dc.date.accessioned2021-03-24T13:00:34Z
dc.date.available2021-03-24T13:00:34Z
dc.date.issued2020
dc.description.abstractFerulic acid (FA) is a natural antioxidant with limited absorption when conjugated with biomolecules but whose free form is readily absorbed in the stomach and, to a lesser extent, in the ileum. The latter sufers from infammation and oxidative stress, so a novel strategy for the delivery of FA in this compartment of the gastrointestinal tract was developed. Using the neutral un-functionalized resin Lewatit® VP OC 1064 MD PH, under optimized conditions, a loading of 144 mg FA/g of dry resin was obtained. By means of an in vitro simulated digestion, an average release of 32 mg FA/g of dry loaded resin (recovery of 22%) was observed in intestinal conditions. The incorporation/release of FA onto/from the resin was confrmed by ATR-FTIR spectroscopy and by HPLC-DAD. This work showed that the free form of FA can efectively be delivered in the small intestine, after immobilization in solid matrices.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMartins, G. N., Spínola, V., & Castilho, P. C. (2020). Release of adsorbed ferulic acid in simulated gastrointestinal conditions. European Food Research and Technology, 246(6), 1297-1306. https://doi.org/10.1007/s00217-020-03489-wpt_PT
dc.identifier.doi10.1007/s00217-020-03489-wpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3194
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFerulic acidpt_PT
dc.subjectAdsorptionpt_PT
dc.subjectReleasept_PT
dc.subjectIn vitro digestion simulationpt_PT
dc.subjectIntestinept_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleRelease of adsorbed ferulic acid in simulated gastrointestinal conditionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1306pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1297pt_PT
oaire.citation.titleEuropean Food Research and Technologypt_PT
oaire.citation.volume246pt_PT
person.familyNameMartins
person.familyNameSpínola
person.familyNameCastilho
person.givenNameGonçalo
person.givenNameVítor
person.givenNamePaula C
person.identifier741627
person.identifierA-4412-2013
person.identifier.ciencia-idE317-F805-6C98
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0002-1869-6208
person.identifier.orcid0000-0003-2456-8613
person.identifier.orcid0000-0002-8303-4286
person.identifier.scopus-author-id57209466494
person.identifier.scopus-author-id54881258000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication89a80160-f611-4310-a8c2-ab6b6a00d560
relation.isAuthorOfPublication6bf71312-4006-4df6-9fbe-d9ed8ce12b06
relation.isAuthorOfPublicationd84fd917-438e-43bf-ac6f-256562481c05
relation.isAuthorOfPublication.latestForDiscovery6bf71312-4006-4df6-9fbe-d9ed8ce12b06

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