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Genotype by sex and genotype by age interactions with sedentary behavior: the Portuguese healthy family study

2014Journal article Open access
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dc.contributor.authorSantos, Daniel M. V.
dc.contributor.authorKatzmarzyk, Peter T.
dc.contributor.authorDiego, Vincent P.
dc.contributor.authorBlangero, John
dc.contributor.authorSouza, Michele C.
dc.contributor.authorFreitas, Duarte L.
dc.contributor.authorChaves, Raquel N.
dc.contributor.authorGomes, Thayse N.
dc.contributor.authorSantos, Fernanda K.
dc.contributor.authorMaia, José A. R.
dc.date.accessioned2021-09-20T14:46:42Z
dc.date.available2021-09-20T14:46:42Z
dc.date.issued2014
dc.description.abstractSedentary behavior (SB) expression and its underlying causal factors have been progressively studied, as it is a major determinant of decreased health quality. In the present study we applied Genotype x Age (GxAge) and Genotype x Sex (GxSex) interaction methods to determine if the phenotypic expression of different SB traits is influenced by an interaction between genetic architecture and both age and sex. A total of 1345 subjects, comprising 249 fathers, 327 mothers, 334 sons and 325 daughters, from 339 families of The Portuguese Healthy Family Study were included in the analysis. SB traits were assessed by means of a 3-d physical activity recall, the Baecke and IPAQ questionnaires. GxAge and GxSex interactions were analyzed using SOLAR 4.0 software. Sedentary behaviour heritability estimates were not always statistically significant (p. 0.05) and ranged from 3% to 27%. The GxSex and GxAge interaction models were significantly better than the single polygenic models for TV (min/day), EEsed (kcal/day), personal computer (PC) usage and physical activty (PA) tertiles. The GxAge model is also significantly better than the polygenic model for Sed (min/day). For EEsed, PA tertiles, PC and Sed, the GxAge interaction was significant because the genetic correlation between SB environments was significantly different from 1. Further, PC and Sed variance heterogeneity among distinct ages were observed. The GxSex interaction was significant for EEsed due to genetic variance heterogeneity between genders and for PC due to a genetic correlation less than 1 across both sexes. Our results suggest that SB expression may be influenced by the interactions between genotype with both sex and age. Further, different sedentary behaviors seem to have distinct genetic architectures and are differentially affected by age and sex.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, D. M., Katzmarzyk, P. T., Diego, V. P., Blangero, J., Souza, M. C., Freitas, D. L., ... & Maia, J. A. (2014). Genotype by sex and genotype by age interactions with sedentary behavior: the Portuguese Healthy Family Study. PloS one, 9(10), e110025. https://doi.org/10.1371/journal.pone.0110025pt_PT
dc.identifier.doi10.1371/journal.pone.0110025pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3644
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relationPhysical activity, health-related physical fitness, somatotype, and metabolic syndrome. A longitudinal study in portuguese nuclear families
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPortuguese healthy familypt_PT
dc.subjectSedentary behaviorpt_PT
dc.subjectGenotypept_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Sociaispt_PT
dc.titleGenotype by sex and genotype by age interactions with sedentary behavior: the Portuguese healthy family studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePhysical activity, health-related physical fitness, somatotype, and metabolic syndrome. A longitudinal study in portuguese nuclear families
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FDES%2F67569%2F2006/PT
oaire.citation.issue10pt_PT
oaire.citation.startPagee110025pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream5876-PPCDTI
person.familyNameKatzmarzyk
person.familyNameFreitas
person.givenNamePeter
person.givenNameDuarte
person.identifier.ciencia-idAA13-1821-A447
person.identifier.orcid0000-0002-9280-6022
person.identifier.orcid0000-0001-6642-3370
person.identifier.ridN-1974-2017
person.identifier.scopus-author-id7005235864
person.identifier.scopus-author-id37096975400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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