Targeting NF-κB signaling pathway in cancer by dietary polyphenols

Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB could act as a tumor activator or tumor suppressant decided by the site of action (organ). Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-κB signaling pathway. They depress the phosphorylation of kinases, inhibit NF-κB translocate into the nucleus as well as interfere interactions between NF-κB and DNA. Through inhibition of NF-κB, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis. This review highlights the anticancer effects of polyphenols on the basis of NF-κB signaling pathway regulation.

Keywords

Dietary polyphenols Cancer Signaling pathway Nuclear factor-jB Phosphorylation . Faculdade de Ciências Exatas e da Engenharia Centro de Química da Madeira

URI

http://hdl.handle.net/10400.13/3198

Citation

Khan, H., Ullah, H., Castilho, P. C. M. F., Gomila, A. S., D'Onofrio, G., Filosa, R., ... & Cao, H. (2020). Targeting NF-κB signaling pathway in cancer by dietary polyphenols. Critical reviews in food science and nutrition, 60(16), 2790-2800. https://doi.org/10.1080/10408398.2019.1661827