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Targeting NF-κB signaling pathway in cancer by dietary polyphenols

2019Journal article Open access
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dc.contributor.authorKhan, Haroon
dc.contributor.authorUllah, Hammad
dc.contributor.authorCastilho, Paula Cristina Machado Ferreira
dc.contributor.authorGomila, Antoni Sureda
dc.contributor.authorD'Onofrio, Grazia
dc.contributor.authorFilosa, Rosanna
dc.contributor.authorWang, Fang
dc.contributor.authorNabavi, Seyed Mohammad
dc.contributor.authorDaglia, Maria
dc.contributor.authorSilva, Ana Sanches
dc.contributor.authorRengasamy, Kannan R. R.
dc.contributor.authorOu, Juanying
dc.contributor.authorZou, Xiaobo
dc.contributor.authorXiao, Jianbo
dc.contributor.authorCao, Hui
dc.date.accessioned2021-03-24T16:09:33Z
dc.date.available2021-03-24T16:09:33Z
dc.date.issued2019
dc.description.abstractBeing a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB could act as a tumor activator or tumor suppressant decided by the site of action (organ). Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-κB signaling pathway. They depress the phosphorylation of kinases, inhibit NF-κB translocate into the nucleus as well as interfere interactions between NF-κB and DNA. Through inhibition of NF-κB, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis. This review highlights the anticancer effects of polyphenols on the basis of NF-κB signaling pathway regulation.pt_PT
dc.description.sponsorshipA. Sureda was supported by the Programme of Promotion of Biomedical Research and Health Sciences (CIBEROBN CB12/ 03/30038).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationKhan, H., Ullah, H., Castilho, P. C. M. F., Gomila, A. S., D'Onofrio, G., Filosa, R., ... & Cao, H. (2020). Targeting NF-κB signaling pathway in cancer by dietary polyphenols. Critical reviews in food science and nutrition, 60(16), 2790-2800. https://doi.org/10.1080/10408398.2019.1661827pt_PT
dc.identifier.doi10.1080/10408398.2019.1661827pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3198
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor and Francispt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDietary polyphenolspt_PT
dc.subjectCancerpt_PT
dc.subjectSignaling pathwaypt_PT
dc.subjectNuclear factor-jBpt_PT
dc.subjectPhosphorylationpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleTargeting NF-κB signaling pathway in cancer by dietary polyphenolspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2800pt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage2790pt_PT
oaire.citation.titleCritical Reviews in Food Science and Nutritionpt_PT
oaire.citation.volume60pt_PT
person.familyNameCastilho
person.givenNamePaula C
person.identifierA-4412-2013
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0002-8303-4286
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd84fd917-438e-43bf-ac6f-256562481c05
relation.isAuthorOfPublication.latestForDiscoveryd84fd917-438e-43bf-ac6f-256562481c05

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