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Polimorfismo do alelo HLA-B27 no desenvolvimento das espondilartropatias
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Advisor(s)
Abstract(s)
A associação da molécula HLA-B27 com a espondilite anquilosante (AS) e outras espondilartropatias (SpA), permanece como uma das mais fortes verificada entre moléculas HLA e doenças humanas. Desde que foi descrita, em 1973, tem sido alvo de intensa investigação na tentativa de compreender o mecanismo patogénico que lhe está subjacente. Este artigo tem como objectivo fazer uma revisão dos conhecimentos actuais relativos à estrutura e polimorfismo da molécula HLA-B27, bem como descrever os modelos propostos para explicar o seu papel no desenvolvimento das espondilartropatias.
The association of HLA-B27 with ankylosing spondylitis (AS), and other spondyloarthropathies (SpA), remains as one of the strongest between HLA molecules and human disease. Since it was reported, in 1973, it has been extensively studied in order to understand the underlying pathogenic mechanism. The objective of this article is to review the current knowledge on the structure and polymorphism of HLA-B27 molecule, as well as describe the main pathogenic hypotheses trying to explain its association with AS.
The association of HLA-B27 with ankylosing spondylitis (AS), and other spondyloarthropathies (SpA), remains as one of the strongest between HLA molecules and human disease. Since it was reported, in 1973, it has been extensively studied in order to understand the underlying pathogenic mechanism. The objective of this article is to review the current knowledge on the structure and polymorphism of HLA-B27 molecule, as well as describe the main pathogenic hypotheses trying to explain its association with AS.
Description
Keywords
Espondilite anquilosante Espondilartropatias MHC HLA-B27 Ankylosing spondylitis Spondyloarthritis . Faculdade de Ciências da Vida
Citation
Peixoto, M. J., Gonzales, T., Spínola, H., Couto, A. R., Gantes Mora, M., Brehm, A., ... & Bruges Armas, J. (2005). Polimorfismo do alelo HLA-B27 no desenvolvimento das espondilartropatias. Acta Médica Portuguesa, 18, 283-294.