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Bench-to-bedside translation of dendrimers: reality or utopia? A concise analysis

2018Journal article Restricted access
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dc.contributor.authorMignani, Serge
dc.contributor.authorRodrigues, João
dc.contributor.authorTomás, Helena
dc.contributor.authorRoy, René
dc.contributor.authorShi, Xiangyang
dc.contributor.authorMajoral, Jean-Pierre
dc.date.accessioned2019-06-27T15:13:15Z
dc.date.available2019-06-27T15:13:15Z
dc.date.issued2018
dc.description.abstractNanomedicine, which is an application of nanotechnologies in healthcare is developed to improve the treatments and lives of patients suffering from a range of disorders and to increase the successes of drug candidates. Within the nanotechnology universe, the remarkable unique and tunable properties of dendrimers have made them promising tools for diverse biomedical applications such as drug delivery, gene therapy and diagnostic. Up-to-date, very few dendrimers has yet gained regulatory approval for systemic administration, why? In this critical review, we briefly focus on the list of desired basic dendrimer requirements for decision-making purpose by the scientists (go/no-go decision), in early development stages, to become clinical candidates, and to move towards Investigational New Drugs (IND) application submission. In addition, the successful translation between research and clinic should be performed by the implementation of a simple roadmap to jump the 'valley of death' successfully.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMignani, S., Rodrigues, J., Tomas, H., Roy, R., Shi, X., & Majoral, J. P. (2018). Bench-to-bedside translation of dendrimers: reality or utopia? A concise analysis. Advanced drug delivery reviews, 136-137, 73-81.pt_PT
dc.identifier.doi10.1016/j.addr.2017.11.007pt_PT
dc.identifier.issn0169-409X
dc.identifier.urihttp://hdl.handle.net/10400.13/2439
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.subjectDendrimerspt_PT
dc.subjectNano carrierspt_PT
dc.subjectClinical translationpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleBench-to-bedside translation of dendrimers: reality or utopia? A concise analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.endPage81pt_PT
oaire.citation.startPage73pt_PT
oaire.citation.titleAdvanced Drug Delivery Reviewspt_PT
oaire.citation.volume136-137pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMignani
person.familyNameRodrigues
person.familyNameTomás
person.familyNameRoy
person.familyNameShi
person.givenNameSerge
person.givenNameJoão
person.givenNameHelena
person.givenNameRené
person.givenNameXiangyang
person.identifier556975
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.ciencia-idBA11-1437-B948
person.identifier.orcid0000-0002-1383-5256
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0001-5638-7302
person.identifier.orcid0000-0001-6785-6645
person.identifier.ridB-6816-2008
person.identifier.ridE-5991-2010
person.identifier.ridA-1289-2007
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id7402953116
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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