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Polyester Dendrimers Based on Bis-MPA for Doxorubicin Delivery

2021Journal article Open access
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dc.contributor.authorGonçalves, Mara
dc.contributor.authorKairys, Visvaldas
dc.contributor.authorRodrigues, João
dc.contributor.authorTomás, Helena
dc.date.accessioned2023-06-16T14:21:05Z
dc.date.available2023-06-16T14:21:05Z
dc.date.issued2021
dc.description.abstractAlthough doxorubicin (DOX) is one of the most used chemotherapeutic drugs due to its efficacy against a wide group of cancer types, it presents severe side effects. As such, intensive research is being carried out to find new nanoscale systems that can help to overcome this problem. Polyester dendrimers based on the monomer 2,2-bis- (hydroxymethyl)propionic acid (bis-MPA) are very promising systems for biomedical applications due to their biodegradability properties. In this study, bis-MPA-based dendrimers were, for the first time, evaluated as DOX delivery vehicles. Generations 4 and 5 of bis-MPA-based dendrimers with hydroxyl groups at the surface were used (B-G4-OH and B-G5-OH), together with dendrimers partially functionalized with amine groups (B-G4-NH2/OH and B-G5-NH2/OH). Partial functionalization was chosen because the main purpose was to compare the effect of different functional groups on dendrimers’ drug delivery behavior without compromising cell viability, which is often affected by dendrimers’ cationic charge. Results revealed that bis-MPA-based dendrimers were cytocompatible, independently of the chemical groups that were present at their surface. The B-G4-NH2/OH and B-G5-NH2/OH dendrimers were able to retain a higher number of DOX molecules, but the in vitro release of the drug was faster. On the contrary, the hydroxyl-terminated dendrimers exhibited a lower loading capacity but were able to deliver the drug in a more sustained manner. These results were in accordance with the cytotoxicity studies performed in several models of cancer cell lines and human mesenchymal stem cells. Overall, the results confirmed that it is possible to tune the drug delivery properties of bis-MPA-based dendrimers by modifying surface functionalization. Moreover, molecular modeling studies provided insights into the nature of the interactions established between the drug and the bis-MPA based dendrimersDOX molecules attach to their surface rather than being physically encapsulated.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves, M., Kairys, V., Rodrigues, J., & Tomás, H. (2021). Polyester Dendrimers Based on Bis-MPA for Doxorubicin Delivery. Biomacromolecules, 23(1), 20-33.pt_PT
dc.identifier.doi10.1021/acs.biomac.1c00455pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5231
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationSELF-ASSEMBLED NANOPARTICLES BASED ON DENDRIMER-POLYETHYLENE GLYCOL-POLYESTER BUILDING BLOCKS FOR DUAL GENE AND DRUG DELIVERY
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCellspt_PT
dc.subjectDendronspt_PT
dc.subjectFunctionalizationpt_PT
dc.subjectMoleculespt_PT
dc.subjectToxicitypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titlePolyester Dendrimers Based on Bis-MPA for Doxorubicin Deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSELF-ASSEMBLED NANOPARTICLES BASED ON DENDRIMER-POLYETHYLENE GLYCOL-POLYESTER BUILDING BLOCKS FOR DUAL GENE AND DRUG DELIVERY
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F88721%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.endPage33pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage20pt_PT
oaire.citation.titleBiomacromoleculespt_PT
oaire.citation.volume23pt_PT
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGonçalves
person.familyNameKairys
person.familyNameRodrigues
person.familyNameTomás
person.givenNameMara
person.givenNameVisvaldas
person.givenNameJoão
person.givenNameHelena
person.identifierK-9893-2013
person.identifier556975
person.identifier.ciencia-id6010-1863-4B11
person.identifier.ciencia-idA716-F916-AFB2
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0002-0332-3548
person.identifier.orcid0000-0002-5427-0175
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-7856-2041
person.identifier.ridB-6816-2008
person.identifier.ridE-5991-2010
person.identifier.scopus-author-id55509603000
person.identifier.scopus-author-id6602925161
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id6508104177
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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