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A non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breast

2018Journal article Open access
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dc.contributor.authorTaunk, Khushman
dc.contributor.authorTaware, Ravindra
dc.contributor.authorMore, Tushar H.
dc.contributor.authorPorto-Figueira, Priscilla
dc.contributor.authorPereira, Jorge A. M.
dc.contributor.authorMohapatra, Rajkishore
dc.contributor.authorSoneji, Dharmesh
dc.contributor.authorCâmara, José S.
dc.contributor.authorNagarajaram, H. A.
dc.contributor.authorRapole, Srikanth
dc.date.accessioned2019-07-25T14:44:00Z
dc.date.available2019-07-25T14:44:00Z
dc.date.issued2018
dc.description.abstractWorldwide, breast invasive ductal carcinoma (IDC) accounts for the majority of the reported cases of this form of cancer. IDC effective management, as for any form of cancer, would greatly benefit from early diagnosis. This, however, due to various socio-economic reasons, is very far for the reality in developing countries like India, where cancer diagnosis is often carried out at late stages when disease management is troublesome. With the present work, we aim to evaluate a simple analytical methodology to identify a set of volatile organic compounds (VOCs) in urine samples, as a biosignature for IDC. Using solid-phase microextraction followed by gas chromatography/mass spectrometry, a panel of 14 urinary VOCs was found to discriminate IDC (n = 65) from a healthy control (HC) group (n = 70) through multivariate statistical treatments. Furthermore, metabolic pathway analysis revealed various dysregulated pathways involved in IDC patients hinting that their detailed investigations could lead to novel mechanistic insights into the disease pathophysiology. In addition, we validated the expression pattern of five of these VOCs namely 2-ethyl-1-hexanol, isolongifolenone, furan, dodecanoic acid, 2-methoxy-phenol in another external cohort of 59 urinary samples (IDC = 32 and HC = 27) and found their expression pattern to be consistent with the primary sample set. To our knowledge, this is the first study exploring breast IDC volatome alterations in Indian patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTaunk, K., Taware, R., More, T. H., Porto-Figueira, P., Pereira, J. A., Mohapatra, R., ... & Rapole, S. (2018). A non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breast. RSC advances, 8(44), 25040-25050.pt_PT
dc.identifier.doi10.1039/C8RA02083Cpt_PT
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/10400.13/2513
dc.language.isoengpt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.relationEXPLORING THE VOLATOME OF NONCOMMUNICABLE DISEASES AS A PROMISING, INNOVATIVE AND INTEGRATING APPROACH FOR THEIR RAPID DIAGNOSTICS. THE CASE STUDY OF CANCER AND NEURODEGENERATIVE DISEASES
dc.relationHNC-i3OMICS - Development of an innovative and integrated platform based on OMICS patterns towards the next generation of cancer diagnosis and management
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDuctal carcinoma of the breastpt_PT
dc.subjectCarcinoma of the breastpt_PT
dc.subjectNon-invasive approachpt_PT
dc.subjectVolatile organic compoundspt_PT
dc.subjectUrinary volatilomept_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleA non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breastpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardTitleEXPLORING THE VOLATOME OF NONCOMMUNICABLE DISEASES AS A PROMISING, INNOVATIVE AND INTEGRATING APPROACH FOR THEIR RAPID DIAGNOSTICS. THE CASE STUDY OF CANCER AND NEURODEGENERATIVE DISEASES
oaire.awardTitleHNC-i3OMICS - Development of an innovative and integrated platform based on OMICS patterns towards the next generation of cancer diagnosis and management
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/New-INDIGO%2F0003%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/Inn-INDIGO%2F0001%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F129630%2F2017/PT
oaire.citation.endPage25050pt_PT
oaire.citation.startPage25040pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume8(44)pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamOE
person.familyNameTAUNK
person.familyNameTaware
person.familyNamePorto-Figueira
person.familyNameAugusto Machado Pereira
person.familyNameCâmara
person.givenNameKHUSHMAN
person.givenNameRavindra
person.givenNamePriscilla
person.givenNameJorge
person.givenNameJosé
person.identifierG-3003-2013
person.identifier.ciencia-idAD11-4860-FB1B
person.identifier.ciencia-idEC12-EE8F-50E8
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.orcid0000-0003-2293-2936
person.identifier.orcid0000-0001-7893-2850
person.identifier.orcid0000-0001-7773-182X
person.identifier.orcid0000-0003-0316-5348
person.identifier.orcid0000-0003-1965-3151
person.identifier.scopus-author-id57195429801
person.identifier.scopus-author-id56724173300
person.identifier.scopus-author-id10140393000
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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