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Advisor(s)
Abstract(s)
A μSPEed microextraction combined with ultra-performance liquid chromatography (UHPLC) with UV
detection was developed for analysing six veterinary antibiotics (tetracycline, chlortetracycline,
oxytetracycline, doxycycline, sulfamethoxazole, and trimethoprim) in environmental samples. To
optimise extraction, 12 sorbent cartridges, sample loading cycles, volumes, and pH were assayed.
The PS/DVB-RP cartridge, three 250 μL sample loading cycles, and two 50-µL elutions with acidified
methanol yielded maximum efficiency. The method was validated with optimised fast
chromatographic separation, showing good linearity (R2 > 0.99), precision (RSD < 20%), and
recoveries between 46-86%. Detection and quantification limits ranged from 0.30-1.23 μg L−1 and
0.92-3.73 μg L−1
, respectively. The optimised μSPEed/UPLC-PDA efficiently analysed environmental
water samples, requiring only 6 min extraction, 6 min analysis, and 500 μL sample, surpassing
alternative methods in speed, workloads and reproducibility. The cost-effective, commercially
available equipment facilitates accessibility for laboratories and adaptability for analysing selected
antibiotics in diverse matrices, including food and environmental samples.
Description
Keywords
Veterinary antibiotics Methodology to survey veterinary antibiotics µSPEed microextraction . Centro de Química da Madeira Faculdade de Ciências Exatas e da Engenharia
Citation
Antos, J., García-Cansino, L., García, M.Á. et al. Improved methodology to survey veterinary antibiotics in environmental samples using µSPEed microextraction followed by ultraperformance liquid chromatography. Commun Chem 8, 68 (2025). https://doi.org/10.1038/s42004-025-01454-w
Publisher
Springer