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Publication
Frequency of the CCR5-A32 mutation in the Atlantic island populations of Madeira, the Azores, Cabo Verde, and São Tomé e Príncipe
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Advisor(s)
Abstract(s)
There is evidence thathe CCR5-A32 mutation confers protection against HIV-1 infection tohomozygous individuals. It is believed that
this mutation spread through Europe with the Vikings and that it has been
subjected to positive selection, leading to a high frequency in Europe
(-10%). We carried out the present study to determine the 32-bp deletion
allele and genotype frequencies of the CCR5 gene (CCR5-A32 ) in the Atlantic island populations of Madeira, the Azores, Cabo Verde, and Säo Tomé e
Principe. These Atlantic archipelagos were all colonized by the Portuguese
in the 15th and 16th centuries, but the latter two received most of their settlers from the West African coast. The frequency of the CCR5-A32 mutation
varies between 0% in Säo Tomé e Principe and 16.5% in the Azores. The
Azores Islands have one of the highest frequencies of homozygotes found in
Europe (4.8%). There are significant differences (P < 0.05) between some
of these populations, for example, between Säo Tomé e Principe and Cabo
Verde, and even within populations (e.g., Portugal, Madeira, and the Azores).
Description
Keywords
DS: CCR5 polymorphism Atlantic islands Madeira (Portugal) Azores (Portugal) Cabo Verde São Tomé e Princípe HIV infection . Faculdade de Ciências da Vida
Citation
Tamira Freitas, António Brehm, and Ana Teresa Fernandes "Frequency of the CCR5-Δ32 Mutation in the Atlantic Island Populations of Madeira, the Azores, Cabo Verde, and São Tomé e Príncipe," Human Biology 78(6), 697-703, (1 December 2006). https://doi.org/10.1353/hub.2007.0011
Publisher
Wayne State University Press