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Frequency of the CCR5-A32 mutation in the Atlantic island populations of Madeira, the Azores, Cabo Verde, and São Tomé e Príncipe

2006Journal article Open access
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dc.contributor.authorFreitas, Tamira
dc.contributor.authorBrehm, António
dc.contributor.authorFernandes, Ana Teresa
dc.date.accessioned2020-12-02T11:45:15Z
dc.date.available2020-12-02T11:45:15Z
dc.date.issued2006
dc.description.abstractThere is evidence thathe CCR5-A32 mutation confers protection against HIV-1 infection tohomozygous individuals. It is believed that this mutation spread through Europe with the Vikings and that it has been subjected to positive selection, leading to a high frequency in Europe (-10%). We carried out the present study to determine the 32-bp deletion allele and genotype frequencies of the CCR5 gene (CCR5-A32 ) in the Atlantic island populations of Madeira, the Azores, Cabo Verde, and Säo Tomé e Principe. These Atlantic archipelagos were all colonized by the Portuguese in the 15th and 16th centuries, but the latter two received most of their settlers from the West African coast. The frequency of the CCR5-A32 mutation varies between 0% in Säo Tomé e Principe and 16.5% in the Azores. The Azores Islands have one of the highest frequencies of homozygotes found in Europe (4.8%). There are significant differences (P < 0.05) between some of these populations, for example, between Säo Tomé e Principe and Cabo Verde, and even within populations (e.g., Portugal, Madeira, and the Azores).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTamira Freitas, António Brehm, and Ana Teresa Fernandes "Frequency of the CCR5-Δ32 Mutation in the Atlantic Island Populations of Madeira, the Azores, Cabo Verde, and São Tomé e Príncipe," Human Biology 78(6), 697-703, (1 December 2006). https://doi.org/10.1353/hub.2007.0011pt_PT
dc.identifier.doi10.1353/hub.2007.0011pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3016
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWayne State University Presspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDS: CCR5 polymorphismpt_PT
dc.subjectAtlantic islandspt_PT
dc.subjectMadeira (Portugal)pt_PT
dc.subjectAzores (Portugal)pt_PT
dc.subjectCabo Verdept_PT
dc.subjectSão Tomé e Princípept_PT
dc.subjectHIV infectionpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleFrequency of the CCR5-A32 mutation in the Atlantic island populations of Madeira, the Azores, Cabo Verde, and São Tomé e Príncipept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage703pt_PT
oaire.citation.startPage697pt_PT
oaire.citation.titleHuman Biologypt_PT
oaire.citation.volume78(6)pt_PT
person.familyNameBrehm
person.givenNameAntonio
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-idAuthor ID 7006085833
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication62d279e2-247a-4652-a370-3e8c2a846e31
relation.isAuthorOfPublication.latestForDiscovery62d279e2-247a-4652-a370-3e8c2a846e31

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