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Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed gold nanoparticles as a novel class of theranostic (radio)pharmaceuticals in cancer therapy

2021Journal article Open access
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dc.contributor.authorMignani, Serge
dc.contributor.authorShi, Xiangyang
dc.contributor.authorCeña, Valentin
dc.contributor.authorRodrigues, João
dc.contributor.authorTomás, Helena
dc.contributor.authorMajoral, Jean-Pierre
dc.date.accessioned2022-02-17T09:25:44Z
dc.date.available2022-02-17T09:25:44Z
dc.date.issued2021
dc.description.abstractNanomedicine represents a very significant contribution in current cancer treatment; in addition to surgical intervention, radiation and chemotherapeutic agents that unfortunately also kill healthy cells, inducing highly deleterious and often life-threatening side effects in the patient. Of the numerous nanoparticles used against cancer, gold nanoparticles had been developed for therapeutic applications. Inter alia, a large variety of den drimers, i.e. soft artificial macromolecules, have turned up as non-viral functional nanocarriers for entrapping drugs, imaging agents, and targeting molecules. This review will provide insights into the design, synthesis, functionalization, and development in biomedicine of engineered functionalized hybrid dendrimer-tangled gold nanoparticles in the domain of cancer theranostic. Several aspects are highlighted and discussed such as 1) dendrimer-entrapped gold(0) hybrid nanoparticles for the targeted imaging and treatment of cancer cells, 2) dendrimer encapsulating gold(0) nanoparticles (Au DENPs) for the delivery of genes, 3) Au DENPs for drug delivery applications, 4) dendrimer encapsulating gold radioactive nanoparticles for radiotherapy, and 5) dendrimer/dendron-complexed gold(III) nanoparticles as technologies to take down cancer cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMignani, S., Shi, X., Ceña, V., Rodrigues, J., Tomas, H., & Majoral, J. P. (2021). Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed gold nanoparticles as a novel class of theranostic (radio) pharmaceuticals in cancer therapy. Journal of Controlled Release, 332, 346-366. https://doi.org/10.1016/j.jconrel.2021.03.003pt_PT
dc.identifier.doi10.1016/j.jconrel.2021.03.003pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4087
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDendrimerspt_PT
dc.subjectDendronspt_PT
dc.subjectGold(0)/(III) nanoparticlespt_PT
dc.subjectGene and drug deliverypt_PT
dc.subjectCancer therapypt_PT
dc.subjectTheranostic strategypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleEngineered non-invasive functionalized dendrimer/dendron-entrapped/complexed gold nanoparticles as a novel class of theranostic (radio)pharmaceuticals in cancer therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.endPage366pt_PT
oaire.citation.startPage346pt_PT
oaire.citation.titleJournal of Controlled Releasept_PT
oaire.citation.volume332pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMignani
person.familyNameShi
person.familyNameCeña
person.familyNameRodrigues
person.familyNameTomás
person.givenNameSerge
person.givenNameXiangyang
person.givenNameValentin
person.givenNameJoão
person.givenNameHelena
person.identifier556975
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person.identifier.ciencia-idBA11-1437-B948
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0002-1383-5256
person.identifier.orcid0000-0001-6785-6645
person.identifier.orcid0000-0001-8928-3681
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-7856-2041
person.identifier.ridA-1289-2007
person.identifier.ridL-1751-2017
person.identifier.ridB-6816-2008
person.identifier.ridE-5991-2010
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id7402953116
person.identifier.scopus-author-id56269211900
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id6508104177
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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