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HLA Class-I diversity in Cameroon: evidence for a North-South structure of genetic variation and relationships with african populations

2011Journal article Restricted access
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dc.contributor.authorSpínola, Hélder
dc.contributor.authorCouto, Ana Rita
dc.contributor.authorPeixoto, Maria José
dc.contributor.authorAnagnostou, Paolo
dc.contributor.authorDestro-Bisol, Giovanni
dc.contributor.authorSpedini, Gabriella
dc.contributor.authorLopéz-Larrea, Carlos
dc.contributor.authorBruges-Armas, Jácome
dc.date.accessioned2018-11-12T09:25:29Z
dc.date.available2018-11-12T09:25:29Z
dc.date.issued2011
dc.description.abstractHLA class I diversity (loci A, B and C) was analysed in four populations, two from North Cameroon (Podokwo and Uldeme) and two from South Cameroon (Ewondo and Bamileke). Northern and southern Cameroon populations show a substantial genetic diversity in terms of haplotype sharing and genetic distances, even despite the low percentage of variance due to differences among populations evidenced by analysis of molecular variance. The signals of differentiation among populations are consistent with their linguistic affiliation, and support previous evidence, based on autosomal microsatellites and protein loci, which has shown that the complex pattern of genetic variation of Cameroon can in part be described by contrasting the northern and southern part of the country. Looking at our results in the more general framework of HLA diversity in sub-Saharan Africa, it turns out that the Podokwo and Uldeme show some genetic links to populations of the southern western branch of the Sahel corridor, while their high frequency of A∗02 and C∗04 alleles is congruent with previously hypothesised introgression of non-sub-Saharan alleles. On the other hand, signals of shared ancestry between the Bamileke and Ewondo and the Bantu speakers from central and southern Africa were detected.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, H., Couto, A. R., Peixoto, M. J., Anagnostou, P., Destro‐Bisol, G., Spedini, G., ... & Bruges‐Armas, J. (2011). HLA Class‐I diversity in Cameroon: evidence for a North‐South structure of genetic variation and relationships with african populations. Annals of human genetics, 75(6), 665-677.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/2153
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherUniversity College Londonpt_PT
dc.subjectCameroonpt_PT
dc.subjectHLApt_PT
dc.subjectBamilekept_PT
dc.subjectEwondopt_PT
dc.subjectPodokwopt_PT
dc.subjectUldemept_PT
dc.subject.pt_PT
dc.subjectEscola Superior de Tecnologias e Gestãopt_PT
dc.titleHLA Class-I diversity in Cameroon: evidence for a North-South structure of genetic variation and relationships with african populationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceLondonpt_PT
oaire.citation.endPage677pt_PT
oaire.citation.startPage665pt_PT
oaire.citation.titleAnnals of Human Geneticspt_PT
oaire.citation.volume75(6)pt_PT
person.familyNameSpínola
person.familyNameCouto
person.familyNameArmas
person.givenNameHélder
person.givenNameAna Rita
person.givenNameJacome
person.identifier2027940
person.identifier682991
person.identifier.ciencia-idFF1A-6A4C-75C9
person.identifier.ciencia-id8413-FBC3-5584
person.identifier.orcid0000-0002-6455-1595
person.identifier.orcid0000-0002-3600-2812
person.identifier.orcid0000-0001-7671-6521
person.identifier.scopus-author-id10242534600
person.identifier.scopus-author-id7005046279
person.identifier.scopus-author-id55931428200
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1ba0f1f6-73c8-46b2-b152-8cd3c90207ed
relation.isAuthorOfPublicatione8cdd84b-ef20-4a7d-97fd-0599e7c45bbe
relation.isAuthorOfPublication887d1c55-c104-403c-b73e-acfa317c4e5d
relation.isAuthorOfPublication.latestForDiscoverye8cdd84b-ef20-4a7d-97fd-0599e7c45bbe

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