Publication
DNA/Dendrimer-based films: a novel material with potential biomedical applications
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Authors
Abstract(s)
Nesta tese de doutoramento, foram desenvolvidos novos materiais híbridos, sob a forma de
filmes finos, essencialmente baseados em interações eletrostáticas estabelecidas entre moléculas de
ácido desoxirribonucleico (ADN) e dendrímeros de poli(amidoamina) (PAMAM). Os dendrímeros
PAMAM são moléculas à escala nanométrica que apresentam multi-valência e um baixo índice de
polidispersão. Esta classe de moléculas tem sido muito estudada para a entrega de genes e fármacos
em células, para além de muitas outras aplicações na área biomédica. Isto apenas é possível devido
às suas propriedades físicas, químicas e estruturais, que permitem a interação eletrostática com
ácidos nucleicos e conjugação à superfície e/ou encapsulamento de fármacos no seu interior. Neste
trabalho, foi tirado proveito da capacidade destas moléculas interagirem com o ADN para obter
novos materiais com aplicações biomédicas promissoras.
In this Ph.D. thesis, novel hybrid materials, in the form of films, were prepared, essentially based on electrostatic interactions established between deoxyribonucleic acid (DNA) molecules and poly(amidoamine) (PAMAM) dendrimers. PAMAM dendrimers are nanoscale molecules that show multi-valency and a low degree of polydispersion. These molecules have been widely studied as gene and drug delivery systems, among other biomedical applications. This is only possible due to their physical, chemical and structural properties, which allow for the electrostatic interaction with nucleic acids, surface conjugation and/or encapsulation of drugs. This work took advantage of the easy interaction of dendrimers with DNA to obtain a new material with promising biomedical applications.
In this Ph.D. thesis, novel hybrid materials, in the form of films, were prepared, essentially based on electrostatic interactions established between deoxyribonucleic acid (DNA) molecules and poly(amidoamine) (PAMAM) dendrimers. PAMAM dendrimers are nanoscale molecules that show multi-valency and a low degree of polydispersion. These molecules have been widely studied as gene and drug delivery systems, among other biomedical applications. This is only possible due to their physical, chemical and structural properties, which allow for the electrostatic interaction with nucleic acids, surface conjugation and/or encapsulation of drugs. This work took advantage of the easy interaction of dendrimers with DNA to obtain a new material with promising biomedical applications.
Description
Keywords
DNA DNA-based hydrogels DNA-based films Stimuli-responsive materials Film deposition techniques Dendrimer-based films Chemistry, speciality in Materials Chemistry . Faculdade de Ciências Exatas e da Engenharia